Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
CORONAVIRUS (GENOME STRUCTURE, REPLICATION)
View through CrossRef
The overview presented in the article is a continuation of the publication on coronaviruses. The paper examines modern data on the structure of the genome and the replication process in various types of coronaviruses that cause diseases in humans and are of medical importance. The structure of the genomes of coronaviruses and the functions of genes that encode the structure of viral particles are presented; describes the function of structural genes and auxiliary genes; the role of genes encoding non-structural proteins in the structure of the viral particle and replication of coronaviruses is shown. The analysis of published studies made it possible to comparatively characterize the genomes of highly dangerous coronaviruses: SARS-CoV, MERS-CoV, SARS-CoV-2, describe their differences in structure and in the process of replication. The review analyzes the structure of the genome and the replication process of coronaviruses at the molecular level, taking into account the characteristics of different types of coronaviruses. To analyze the genetic structures and replication of coronaviruses, modern literary sources, articles in the world’s leading medical and biological journals were used.
Title: CORONAVIRUS (GENOME STRUCTURE, REPLICATION)
Description:
The overview presented in the article is a continuation of the publication on coronaviruses.
The paper examines modern data on the structure of the genome and the replication process in various types of coronaviruses that cause diseases in humans and are of medical importance.
The structure of the genomes of coronaviruses and the functions of genes that encode the structure of viral particles are presented; describes the function of structural genes and auxiliary genes; the role of genes encoding non-structural proteins in the structure of the viral particle and replication of coronaviruses is shown.
The analysis of published studies made it possible to comparatively characterize the genomes of highly dangerous coronaviruses: SARS-CoV, MERS-CoV, SARS-CoV-2, describe their differences in structure and in the process of replication.
The review analyzes the structure of the genome and the replication process of coronaviruses at the molecular level, taking into account the characteristics of different types of coronaviruses.
To analyze the genetic structures and replication of coronaviruses, modern literary sources, articles in the world’s leading medical and biological journals were used.
Related Results
Single‐Molecule Optical Replication Mapping (ORM) Suggests Human Replication Timing is Regulated by Stochastic Initiation
Single‐Molecule Optical Replication Mapping (ORM) Suggests Human Replication Timing is Regulated by Stochastic Initiation
DNA replication timing is regulated by the timing of initiation across the genome. However, there is no consensus as to how initiation timing is regulated. Deterministic models con...
Identification of 1600 replication origins in S. cerevisiae
Identification of 1600 replication origins in S. cerevisiae
Abstract
There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood. In ...
Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)
Restriction of SARS-CoV-2 replication by receptor transporter protein 4 (RTP4)
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is subject to restriction by several interferon-inducible host proteins. To identify novel factors t...
Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis
Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis
ABSTRACT
Similar to other positive-strand RNA viruses, hepatitis C virus (HCV) causes massive rearrangements of intracellular membranes, resulting in a membranous web (MW...
Abstract 1777: Genome-wide identification of replication-associated breakpoints.
Abstract 1777: Genome-wide identification of replication-associated breakpoints.
Abstract
Previous studies have defined sequences that are difficult to replicate and, consequently, are more vulnerable to replication-associated breaks and recombin...
Identification of 1600 replication origins in S. cerevisiae
Identification of 1600 replication origins in S. cerevisiae
Abstract
There are approximately 500 known origins of replication in the yeast genome, and the process by which DNA replication initiates at these locations is well understood. In ...
Single-cell replication profiling reveals stochastic regulation of the mammalian replication-timing program
Single-cell replication profiling reveals stochastic regulation of the mammalian replication-timing program
AbstractIn mammalian cells, distinct replication domains (RDs), corresponding to structural units of chromosomes called topologically-associating domains (TADs), replicate at diffe...
Exploiting DNA Replication Stress for Cancer Treatment
Exploiting DNA Replication Stress for Cancer Treatment
Abstract
Complete and accurate DNA replication is fundamental to cellular proliferation and genome stability. Obstacles that delay, prevent, or terminate DNA replica...