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Factor VII in Subjects at Risk for Thromboembolism: Activation or Increased Synthesis?

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In this study the preliminary results obtained by investigating factor VII:antigen and activity in 38 subjects with arterial disease of the extremities are reported. The antigen determination (VIl:Ag) was performed by using an inhibitor neutralization assay; factor VII activity (VIl:C) was determined by one-stage assay with human factor VII artificially depleted plasma. All the patients showed increased levels of VIl:C and VIl·Ag compared to the reference population (p < 0.001). There is a significant correlation between VIl:C and VIl:Ag (r = 0.47), but the ratio VIl:C/VIl:Ag is slightly increased. Our results confirm that elevated levels of factor VII are present in patients with tendency to thrombosis.

S. Karger AG

M. Orlando O. Leri G. Macioce G. Mattia G.M. Ferri

Title: Factor VII in Subjects at Risk for Thromboembolism: Activation or Increased Synthesis?

Description:

In this study the preliminary results obtained by investigating factor VII:antigen and activity in 38 subjects with arterial disease of the extremities are reported.

The antigen determination (VIl:Ag) was performed by using an inhibitor neutralization assay; factor VII activity (VIl:C) was determined by one-stage assay with human factor VII artificially depleted plasma.

All the patients showed increased levels of VIl:C and VIl·Ag compared to the reference population (p < 0.

001).

There is a significant correlation between VIl:C and VIl:Ag (r = 0.

47), but the ratio VIl:C/VIl:Ag is slightly increased.

Our results confirm that elevated levels of factor VII are present in patients with tendency to thrombosis.

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