Exploring the mechanism of action of Buyang Huanwu Tang in treating post-stroke sequelae based on network pharmacology

Objective: To explore the mechanism of action of Buyang Huanwu Tang in treating post-stroke sequelae through network pharmacology methods. Method: Based on the TCMSP database, screen the active ingredients in Buyang Huanwu Tang. Screening relevant targets for post-stroke sequelae through Gene Card database and OMIM database, and drawing Venn diagrams using Venn package in R language, and using Cytoscape 3.10.3 Software is used to construct a network of "prescription drugs active ingredients disease targets", followed by enrichment analysis of GO and KEGG pathways. Finally, the analysis results are molecular docked to identify potential targets for the treatment of post-stroke sequelae with Buyang Huanwu Tang and exert therapeutic effects. Result: A total of 63 potential active ingredients were screened out, and 67 potential targets were predicted. GO and KEGG analysis showed that Buyang Huanwu Tang can improve post-stroke sequelae symptoms by regulating the apoptotic signaling pathway, membrane raft, DNA binding transcription factor binding, and so on. Conclusion: This study elucidates that Buyang Huanwu Tang can exert therapeutic effects through a multi-component synergistic mode of action. These findings provide new ideas and scientific basis for the mechanism of action of Buyang Huanwu Tang in treating post-stroke sequelae.