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Complete Genome Sequence of GII.9 Norovirus
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Abstract
Norovirus is recognized as one of the leading causes of acute gastroenteritis outbreaks. Genotype GII.9 was first detected in Norfolk, USA in 1997. However, the complete genome sequence of this genotype was not established yet. In this study, a complete genome sequence of a GII.9[P7] norovirus, marked as SCD1878, from a patient was established using a high-throughput sequencing and rapid amplification of cDNA ends (RACE) technology. The complete genome sequence of SCD1878_GII.9P7 was 7544 nucleotides (nts) in length with a 3’ poly (A) tail, including three open reading frames. Homology analysis indicated that SCD1878_GII.9P7 shares 92.1%-92.3% identity with GII.P7 (AB258331 and AB039777) and 96.7%-97.4% identity with GII.9 (AY038599 and DQ379715) sequences. The results suggested that SCD1878 is a member of GII.P7 for P genotypes and GII.9 for genotypes. The viral sequence filled the gap in the whole genome level of the GII.9 genotype.
Springer Science and Business Media LLC
Title: Complete Genome Sequence of GII.9 Norovirus
Description:
Abstract
Norovirus is recognized as one of the leading causes of acute gastroenteritis outbreaks.
Genotype GII.
9 was first detected in Norfolk, USA in 1997.
However, the complete genome sequence of this genotype was not established yet.
In this study, a complete genome sequence of a GII.
9[P7] norovirus, marked as SCD1878, from a patient was established using a high-throughput sequencing and rapid amplification of cDNA ends (RACE) technology.
The complete genome sequence of SCD1878_GII.
9P7 was 7544 nucleotides (nts) in length with a 3’ poly (A) tail, including three open reading frames.
Homology analysis indicated that SCD1878_GII.
9P7 shares 92.
1%-92.
3% identity with GII.
P7 (AB258331 and AB039777) and 96.
7%-97.
4% identity with GII.
9 (AY038599 and DQ379715) sequences.
The results suggested that SCD1878 is a member of GII.
P7 for P genotypes and GII.
9 for genotypes.
The viral sequence filled the gap in the whole genome level of the GII.
9 genotype.
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