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Effects of chlorhexidine diacetate on Candida albicans, C. glabrata and Saccharomyces cerevisiae
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S.J. HIOM, J.R. FURR, A.D. RUSSELL AND J.R. DICKINSON, 1992. The effects of chlorhexidine diacetate (CHA) on Candida albicans, C. glabrata and wild‐type and mannan, and permeability mutants of Saccharomyces cerevisiae have been studied. A CHA concentration of 10 μg/ml had little lethal activity against the Candida strains, but was more effective against S. cerevisiae. Concentrations of 100 and especially 1000 μg/ml brought about a much more rapid death of cells. 2‐Mercaptoethanol enhanced the activity of CHA to some extent. Some of the mutant strains of S. cerevisiae were rather more sensitive than the wild‐type strain. The age of cultures of C. albicans and C. glabrata influenced their response to CHA.
Title: Effects of chlorhexidine diacetate on Candida albicans, C. glabrata and Saccharomyces cerevisiae
Description:
S.
J.
HIOM, J.
R.
FURR, A.
D.
RUSSELL AND J.
R.
DICKINSON, 1992.
The effects of chlorhexidine diacetate (CHA) on Candida albicans, C.
glabrata and wild‐type and mannan, and permeability mutants of Saccharomyces cerevisiae have been studied.
A CHA concentration of 10 μg/ml had little lethal activity against the Candida strains, but was more effective against S.
cerevisiae.
Concentrations of 100 and especially 1000 μg/ml brought about a much more rapid death of cells.
2‐Mercaptoethanol enhanced the activity of CHA to some extent.
Some of the mutant strains of S.
cerevisiae were rather more sensitive than the wild‐type strain.
The age of cultures of C.
albicans and C.
glabrata influenced their response to CHA.
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