Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The autopod: Its formation during limb development
View through CrossRef
The autopod, including the mesopodium and the acropodium, is the most distal part of the tetrapod limb, and developmental mechanisms of autopod formation serve as a model system of pattern formation during development. Cartilage rudiments of the autopod develop after proximal elements have differentiated. The autopod region is marked by a change in the expression of two homeobox genes: future autopod cells are first Hoxa11/Hoxa13‐double‐positive and then Hoxa13‐single‐positive. The change in expression of these Hox genes is controlled by upstream mechanisms, including the retinoic acid pathway, and the expression of Hoxa13 is connected to downstream mechanisms, including the autopod‐specific cell surface property mediated by molecules, including cadherins and ephrins/Ephs, for cell‐to‐cell communication and recognition. Comparative analyses of the expression of Hox genes in fish fins and tetrapod limb buds support the notion on the origin of the autopod in vertebrates. This review will focus on the cellular and molecular regulation of the formation of the autopod during development and evolutionary developmental aspects of the origin of the autopod.
Title: The autopod: Its formation during limb development
Description:
The autopod, including the mesopodium and the acropodium, is the most distal part of the tetrapod limb, and developmental mechanisms of autopod formation serve as a model system of pattern formation during development.
Cartilage rudiments of the autopod develop after proximal elements have differentiated.
The autopod region is marked by a change in the expression of two homeobox genes: future autopod cells are first Hoxa11/Hoxa13‐double‐positive and then Hoxa13‐single‐positive.
The change in expression of these Hox genes is controlled by upstream mechanisms, including the retinoic acid pathway, and the expression of Hoxa13 is connected to downstream mechanisms, including the autopod‐specific cell surface property mediated by molecules, including cadherins and ephrins/Ephs, for cell‐to‐cell communication and recognition.
Comparative analyses of the expression of Hox genes in fish fins and tetrapod limb buds support the notion on the origin of the autopod in vertebrates.
This review will focus on the cellular and molecular regulation of the formation of the autopod during development and evolutionary developmental aspects of the origin of the autopod.
Related Results
Body image and perception among adults with and without phantom limb pain
Body image and perception among adults with and without phantom limb pain
AbstractBackgroundFollowing lower‐limb amputation, phantom limb pain (i.e., pain perceived as coming from the amputated portion of the limb) is common. Phantom limb pain may be ass...
Hydrocolloid Membrane Dressing in Shearing Injuries in the Distal Part of the Pelvic Limbs in Dogs
Hydrocolloid Membrane Dressing in Shearing Injuries in the Distal Part of the Pelvic Limbs in Dogs
Background: Shearing wounds on the limbs of dogs usually affect the regions distally from the radiocarpal joint at the thoracic limb and from the tibiotarsal joint at the pelvic li...
The befuddling nature of mouse lemur hands and feet at Bezà Mahafaly, SW Madagascar
The befuddling nature of mouse lemur hands and feet at Bezà Mahafaly, SW Madagascar
The reddish‐gray mouse lemur (Microcebus griseorufus) possesses striking phenotypic and behavioral variation. This project investigates differences in autopod proportions in neighb...
Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development
Proximal tubule cells contribute to the thin descending limb of the loop of Henle during mouse kidney development
Abstract
Background
The thin descending limb of the loop of Henle is crucial for urine concentration, as it facilitates passive...
Vertebrate Embryo: Limb Development
Vertebrate Embryo: Limb Development
AbstractVertebrate limbs develop from small buds of mesenchyme cells encased in ectoderm. Limb development is an excellent model system for studying embryonic growth and pattern fo...
THE IDEAL PHYSICAL THERAPIST FROM THE PERSPECTIVE OF INDIVIDUALS WITH LIMB LOSS
THE IDEAL PHYSICAL THERAPIST FROM THE PERSPECTIVE OF INDIVIDUALS WITH LIMB LOSS
BACKGROUND: Effective rehabilitation after limb loss is necessary to maximize function and promote independence. Physical therapists (PT) are one of the primary drivers of the reha...
Amputação Parcial de Membro e Adaptação Protética em Égua Puro-Sangue Inglês
Amputação Parcial de Membro e Adaptação Protética em Égua Puro-Sangue Inglês
Background: Traditionally, severe limb injuries in horses often result in euthanasia. However, advancements in veterinary medicine allow for the treatment and rehabilitation of man...
Trunk and Lower Limb Mechanics during Multi-Directional Cutting in Dominant and Non-dominant Limbs of Athletes: Implications for Anterior Cruciate Ligament Injury Risk
Trunk and Lower Limb Mechanics during Multi-Directional Cutting in Dominant and Non-dominant Limbs of Athletes: Implications for Anterior Cruciate Ligament Injury Risk
Background
Understanding the influence of limb dominance and cutting angles on trunk and lower limb biomechanics and trunk muscle activation during multidirecti...