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Potassium markedly potentiates the effect of veratridine on dopamine release from rat superfused striatal ribbons
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Abstract
The effects of veratridine-induced depolarization on [3H]dopamine ([3H]DA) release in the presence of a physiological (5 Mm) or a depolarizing (25 Mm) concentration of K+ were studied in-vitro in rat superfused striatal ribbons. A combination of the two depolarizing agents induced a marked potentiation in the overflow of [3H]DA, giving an overall 3- to 5-fold increase in veratridine activity. This potentiation was completely antagonized by tetrodotoxin (100 Nm). These studies indicated that K+-induced depolarization can increase the potency of veratridine in releasing dopamine from terminals.
Oxford University Press (OUP)
Title: Potassium markedly potentiates the effect of veratridine on dopamine release from rat superfused striatal ribbons
Description:
Abstract
The effects of veratridine-induced depolarization on [3H]dopamine ([3H]DA) release in the presence of a physiological (5 Mm) or a depolarizing (25 Mm) concentration of K+ were studied in-vitro in rat superfused striatal ribbons.
A combination of the two depolarizing agents induced a marked potentiation in the overflow of [3H]DA, giving an overall 3- to 5-fold increase in veratridine activity.
This potentiation was completely antagonized by tetrodotoxin (100 Nm).
These studies indicated that K+-induced depolarization can increase the potency of veratridine in releasing dopamine from terminals.
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