Whole Genome Sequencing of ESBL Producing Klebsiella pneumoniae: Systematic Literature Review

Objective: It was aimed to conduct a thorough and systematic examination of the available literature referring to the importance of incorporating Whole genome sequencing in interpreting and assessing the genetic structure of ESBL producing Klebsiella pneumoniae   Methodology: This systematic literature search was conducted across multiple databases, mainly including PubMed, Scopus and Web of Science focusing on antimicrobial resistance and genomics. Results:The review amalgamates an extensive range of research studies, hedging into the genetic determinants, evolutionary patterns, and dissemination mechanisms of Extended spectrum beta lactamase producing Klebsiella pneumoniae from across the globe. Conscientious and careful examination of the relevant studies included in this systematic literature review, together intend to enlighten the thoroughness of comprehension provided by Whole genome sequencing in straightening out the foundations of genetics of ESBL producing Klebsiella pneumoniae. It endeavors to characterize its identified genes responsible for resistance, mutations, mobile genetic elements and the factors associated with dissemination of its resistance traits. Conclusion: This systematic literature review compiles together and provides not only with a valuable summary of the key factors involved in the understanding of the crucial elements, complex interaction and entangled dynamics of the genetic elements connected with antimicrobial resistance, but also supplements the efforts being carried out globally to combat antimicrobial resistance associated in particular with ESBL producing Klebsiella pneumoniae for effective infection prevention and control.