Unveiling the Link: HLA-B27 Genetic Marker and Interleukin Levels in Psoriatic Arthritis Patients

This study aimed to examine the occurrence of Human leukocyte antigen-B27 (HLA-B27) and its subtypes, alongside the levels of the inflammatory markers Interleukin-17 and Interleukin-23 in individuals diagnosed with psoriatic arthritis (PsA), a multifaceted, polygenic disorder strongly influenced by genetic factors. An observational cross-sectional study was carried out that included patients who satisfied the CASPAR criteria for Psoriatic arthritis. This study revealed a male predominance among PsA patients and an association between HLA-B27 positivity and an earlier age of onset. Notably, theHLA-B27 subtypes B27:05, B27:04 and HLA-B27:02, B27:07 were not detected in any HLA-B27 positive Psoriatic arthritis patients in our study. Additionally, elevated levels of Interleukin-17 and Interleukin-23 were observed, particularly in Human leukocyte antigen-B27 positive PsA patients.