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ChemInform Abstract: Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3‐Substituted 2‐(trifluoromethyl)piperidines.
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AbstractThe straightforward regio‐ and diastereoselective title reaction allows for the synthesis of a broad range of 3‐substituted 2‐(trifluoromethyl)piperidines which are formed via ring‐opening of a (trifluoromethyl)aziridinium intermediate by various electrophiles including iodine, secondary amines, aniline, alcohols and thiols, sodium phenolate and water as well as C‐anions such as cyanide.
Title: ChemInform Abstract: Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3‐Substituted 2‐(trifluoromethyl)piperidines.
Description:
AbstractThe straightforward regio‐ and diastereoselective title reaction allows for the synthesis of a broad range of 3‐substituted 2‐(trifluoromethyl)piperidines which are formed via ring‐opening of a (trifluoromethyl)aziridinium intermediate by various electrophiles including iodine, secondary amines, aniline, alcohols and thiols, sodium phenolate and water as well as C‐anions such as cyanide.
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