Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
ChemInform Abstract: Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3‐Substituted 2‐(trifluoromethyl)piperidines.
View through CrossRef
AbstractThe straightforward regio‐ and diastereoselective title reaction allows for the synthesis of a broad range of 3‐substituted 2‐(trifluoromethyl)piperidines which are formed via ring‐opening of a (trifluoromethyl)aziridinium intermediate by various electrophiles including iodine, secondary amines, aniline, alcohols and thiols, sodium phenolate and water as well as C‐anions such as cyanide.
Title: ChemInform Abstract: Stereoselective Rearrangement of (Trifluoromethyl)prolinols to Enantioenriched 3‐Substituted 2‐(trifluoromethyl)piperidines.
Description:
AbstractThe straightforward regio‐ and diastereoselective title reaction allows for the synthesis of a broad range of 3‐substituted 2‐(trifluoromethyl)piperidines which are formed via ring‐opening of a (trifluoromethyl)aziridinium intermediate by various electrophiles including iodine, secondary amines, aniline, alcohols and thiols, sodium phenolate and water as well as C‐anions such as cyanide.
Related Results
Agrandissement de cycle : synthèse de pipéridines et d'azépanes α-trifluorométhylés
Agrandissement de cycle : synthèse de pipéridines et d'azépanes α-trifluorométhylés
L'introduction d'atomes de fluor sur des composés organiques peut avoir une forte influence sur les propriétés physico-chimiques, ainsi que sur l'activité biologique de ces composé...
Extended Duration of DH–JH Rearrangement in Immunoglobulin Heavy Chain Transgenic Mice: Implications for Regulation of Allelic Exclusion
Extended Duration of DH–JH Rearrangement in Immunoglobulin Heavy Chain Transgenic Mice: Implications for Regulation of Allelic Exclusion
Here we show that suppression of VH–DJH rearrangement in mice bearing a μ heavy (H) chain transgene (μ-tg mice) is associated with an extended period of DH–JH rearrangement, the fi...
Synthesis of 2‐(Trifluoromethyl)Azetidines by Strain‐Release Reactions of 2‐(Trifluoromethyl)‐1‐Azabicyclo[1.1.0]Butanes
Synthesis of 2‐(Trifluoromethyl)Azetidines by Strain‐Release Reactions of 2‐(Trifluoromethyl)‐1‐Azabicyclo[1.1.0]Butanes
Abstract
Substituted azetidines are privileged heterocyclic scaffolds in medicinal chemistry and have become synthetic targets of high intere...
Développements méthodologiques de la cyclisation d’aza-Prins et aminolyse de lactone pour la synthèse de nouvelles structures peptidomimétiques- pipéridines
Développements méthodologiques de la cyclisation d’aza-Prins et aminolyse de lactone pour la synthèse de nouvelles structures peptidomimétiques- pipéridines
Les tétrahydropyranes et les pipéridines sont des motifs que l'on retrouve dans de nombreuses molécules naturelles bioactives. L'intérêt pour ces familles de composés ne cesse de c...
The enantioselective Organocatalytic [1,2]-Rearrangement of Allylic Ammonium Ylides
The enantioselective Organocatalytic [1,2]-Rearrangement of Allylic Ammonium Ylides
The [1,2]-rearrangement of allylic ammonium ylides is traditionally observed as a competitive minor pathway alongside the thermally allowed [2,3]-sigmatropic rearrangement. The cha...
The Enantioselective Organocatalytic [1,2]-Rearrangement of Allylic Ammonium Ylides
The Enantioselective Organocatalytic [1,2]-Rearrangement of Allylic Ammonium Ylides
The [1,2]-rearrangement of allylic ammonium ylides is traditionally observed as a competitive minor pathway alongside the thermally allowed [2,3]-sigmatropic rearrangement. The cha...
Survival Impact of Time Repeated bcl2/IgH Rearrangement Measurements in Follicular Lymphoma Patients Treated with Front-Line Autotransplantation in the GELF-94 Trial by the GELA.
Survival Impact of Time Repeated bcl2/IgH Rearrangement Measurements in Follicular Lymphoma Patients Treated with Front-Line Autotransplantation in the GELF-94 Trial by the GELA.
Abstract
In the autotranplantation framework, an undetectable MRD before ASCT seems to protect for disease relapse and to increase survival. Using data from the GELF...
Synthesis of some trifluoromethyl substituted 1‐methylpyrazoles
Synthesis of some trifluoromethyl substituted 1‐methylpyrazoles
AbstractThe major products from the reaction of β‐alkoxyvinyl trifluoromethyl ketones 1a‐c with methylhydrazine (2) in absolute ethanol are the 3‐(trifluoromethyl)‐substituted‐1‐me...