Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Active metal template synthesis of rotaxanes from BINOL-phosphate macrocycles
View through CrossRef
A new active metal template synthesis of [2]rotaxanes is described. We demonstrate the use of macrocyclic BINOL-phosphates as ligands for the Cu(I)-mediated alkyne-azide cycloaddition, establishing a mechanical bond. The influence of thread length and macrocycle size was investigated in detail and different chiral rotaxanes could be isolated in good yields. In addition, we found that functionalized alkynes, featuring hydroxyl- or amino-groups, were well-tolerated. This work not only delivers a generally applicable active template method for generating BINOL-phosphate containing rotaxanes, but also represents the first active metal template approach without nitrogen-based donors in the macrocycle.
American Chemical Society (ACS)
Title: Active metal template synthesis of rotaxanes from BINOL-phosphate macrocycles
Description:
A new active metal template synthesis of [2]rotaxanes is described.
We demonstrate the use of macrocyclic BINOL-phosphates as ligands for the Cu(I)-mediated alkyne-azide cycloaddition, establishing a mechanical bond.
The influence of thread length and macrocycle size was investigated in detail and different chiral rotaxanes could be isolated in good yields.
In addition, we found that functionalized alkynes, featuring hydroxyl- or amino-groups, were well-tolerated.
This work not only delivers a generally applicable active template method for generating BINOL-phosphate containing rotaxanes, but also represents the first active metal template approach without nitrogen-based donors in the macrocycle.
Related Results
Crown Ether Active Template Synthesis of Rotaxanes
Crown Ether Active Template Synthesis of Rotaxanes
Abstract Rotaxanes are interlocked molecules that consist of a macrocycle encircling a stoppered thread. The ability to control relative component positions makes rotaxanes ideal b...
P0883HEALTHY FEMALES EXCRETE MORE PHOSPHATE THAN MALES IN RESPONSE TO AN ORAL CHALLENGE
P0883HEALTHY FEMALES EXCRETE MORE PHOSPHATE THAN MALES IN RESPONSE TO AN ORAL CHALLENGE
Abstract
Background and Aims
There are disparities in the diagnosis, treatment and prognosis for cardiovascular disease (CVD) be...
Novel phosphate-based cements for clinical applications
Novel phosphate-based cements for clinical applications
This Thesis aims at the development of two novel families of inorganic phosphate cements with suitable characteristics for clinical applications in hard tissue regeneration or repl...
Glutathione induces ArabidopsisPHT1;5gene via WRKY75 transcription factor to regulate phosphate homeostasis
Glutathione induces ArabidopsisPHT1;5gene via WRKY75 transcription factor to regulate phosphate homeostasis
AbstractPhosphorus is a macronutrient that regulates a wide range of physiological processes, including plant growth and development. The scarcity of bioavailable phosphate is ofte...
P0894OBESITY IMPAIRS THE ACUTE RESPONSE TO AN ORAL PHOSPHATE CHALLENGE
P0894OBESITY IMPAIRS THE ACUTE RESPONSE TO AN ORAL PHOSPHATE CHALLENGE
Abstract
Background and Aims
T Obesity is an increasing health problem world-wide. People who are overweight or obese are at gre...
Harnessing Point–Planar Chirality Synergy: Crystallization‐Enabled Resolution of Pillar[5]arene Rotaxanes With Tunable Circularly Polarized Luminescence
Harnessing Point–Planar Chirality Synergy: Crystallization‐Enabled Resolution of Pillar[5]arene Rotaxanes With Tunable Circularly Polarized Luminescence
ABSTRACT
Immobilizing the planar chirality inherent to pillar[5]arene remains a challenge in supramolecular chemistry. Herein, we report a ra...
3,3'-Linked BINOL macrocycles: optimized synthesis of crown ethers featuring one or two BINOL units
3,3'-Linked BINOL macrocycles: optimized synthesis of crown ethers featuring one or two BINOL units
Chiral macrocycles hold significant importance in various scientific fields due to their unique structural and chemical properties. By controlling their size, shape, and substituen...
Drilling Optimization on Gyda Development Project: A Case Study
Drilling Optimization on Gyda Development Project: A Case Study
ABSTRACT
BP Norway's North Sea Gyda Field development commenced when a nine slot template was installed and the first template well spudded in November 1987. Eigh...