Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Structure of the WD40‐domain of human ATG16L1
View through CrossRef
AbstractAutophagy‐related protein ATG16L1 is a component of the mammalian ATG12∼ATG5/ATG16L1 complex, which acts as E3‐ligase to catalyze lipidation of LC3 during autophagosome biogenesis. The N‐terminal part of ATG16L1 comprises the ATG5‐binding site and coiled‐coil dimerization domain, both also present in yeast ATG16 and essential for bulk and starvation induced autophagy. While absent in yeast ATG16, mammalian ATG16L1 further contains a predicted C‐terminal WD40‐domain, which has been shown to be involved in mediating interaction with diverse factors in the context of alternative functions of autophagy, such as inflammatory control and xenophagy. In this work, we provide detailed information on the domain boundaries of the WD40‐domain of human ATG16L1 and present its crystal structure at a resolution of 1.55 Å.
Title: Structure of the WD40‐domain of human ATG16L1
Description:
AbstractAutophagy‐related protein ATG16L1 is a component of the mammalian ATG12∼ATG5/ATG16L1 complex, which acts as E3‐ligase to catalyze lipidation of LC3 during autophagosome biogenesis.
The N‐terminal part of ATG16L1 comprises the ATG5‐binding site and coiled‐coil dimerization domain, both also present in yeast ATG16 and essential for bulk and starvation induced autophagy.
While absent in yeast ATG16, mammalian ATG16L1 further contains a predicted C‐terminal WD40‐domain, which has been shown to be involved in mediating interaction with diverse factors in the context of alternative functions of autophagy, such as inflammatory control and xenophagy.
In this work, we provide detailed information on the domain boundaries of the WD40‐domain of human ATG16L1 and present its crystal structure at a resolution of 1.
55 Å.
Related Results
ATG16L1 functions in cell homeostasis beyond autophagy
ATG16L1 functions in cell homeostasis beyond autophagy
Atg16‐like (ATG16L) proteins were identified in higher eukaryotes for their resemblance to Atg16, a yeast protein previously characterized as a subunit of the Atg12‐Atg5/Atg16 comp...
Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins
Molecular bases of the interactions of ATG16L1 with FIP200 and ATG8 family proteins
Abstract
Macroautophagy maintains cellular and organismal homeostasis, and entails de novo synthesis of double-membrane autophagosome. The effective formation of autophagos...
Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against Toxoplasma gondii
Role of Mouse and Human Autophagy Proteins in IFN-γ–Induced Cell-Autonomous Responses against Toxoplasma gondii
Abstract
IFN-γ mediates cellular innate immunity against an intracellular parasite, Toxoplasma gondii, by inducing immunity-related GTPases such as p47 IFN-γ–regulat...
Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production
AbstractAutophagy is an essential self-digestion machinery for cell survival and homoeostasis. Membrane elongation is fundamental, as it drives the formation of the double-membrane...
Identification of
WD40
gene family in
Prunus mume
and its expression level under light illumination
Identification of
WD40
gene family in
Prunus mume
and its expression level under light illumination
The
WD40
gene family in
Prunusmume
was identified by bioinformatics analysis., The evolution and function of...
Genome-wide identification of WD40 transcription factors and their regulation of the MYB-bHLH-WD40 (MBW) complex related to anthocyanin synthesis in Qingke (Hordeum vulgare L. var. nudum Hook. f.)
Genome-wide identification of WD40 transcription factors and their regulation of the MYB-bHLH-WD40 (MBW) complex related to anthocyanin synthesis in Qingke (Hordeum vulgare L. var. nudum Hook. f.)
Abstract
Background
WD40 transcription factors, a large gene family in eukaryotes, are involved in a variety of growth regulation and development pa...
Molecular features of Myosin F adapted for driving actin flows in
Toxoplasma gondii
Molecular features of Myosin F adapted for driving actin flows in
Toxoplasma gondii
Abstract
Toxoplasma gondii
(
T. gondii
) is a single-celled Apicomplexan parasite that reli...
FIP200 regulates targeting of Atg16L1 to the isolation membrane
FIP200 regulates targeting of Atg16L1 to the isolation membrane
Autophagosome formation is a dynamic process that is strictly controlled by autophagy‐related (Atg) proteins. However, how these Atg proteins are recruited to the autophagosome for...