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Copper-catalyzed arylation of N-hydroxy sulfonamides with boronic acid to synthesize N-aryl sulfonamides
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A metal-free oxidative Chan−Lam coupling reaction of sulfonamides with aryl boronic acid has been developed for the synthesis of N-aryl sulfonamides. The method features copper acetate and triethyl amine base were used to enable the C–N bond formation. Moreover, this straightforward process leads to a broad range of N-aryl substituted sulfonamides bearing diverse functional groups in good to excellent yields without any expensive catalyst, ligand, and at room temperature.
Title: Copper-catalyzed arylation of N-hydroxy sulfonamides with boronic acid to synthesize N-aryl sulfonamides
Description:
A metal-free oxidative Chan−Lam coupling reaction of sulfonamides with aryl boronic acid has been developed for the synthesis of N-aryl sulfonamides.
The method features copper acetate and triethyl amine base were used to enable the C–N bond formation.
Moreover, this straightforward process leads to a broad range of N-aryl substituted sulfonamides bearing diverse functional groups in good to excellent yields without any expensive catalyst, ligand, and at room temperature.
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