Formulation, Development and Evaluation of Nanoemulgel of Cyproheptadine Hydrochloride

The objective of present research work was to formulate Nanoemulgel of Cyproheptadine HCl for the treatment of allergic reaction. By using 32 full Factorial Design optimization of Cyproheptadine HCl Nanoemulsion was done & optimized Nanoemulsion was incorporated into gel & Nanoemulgel of Cyproheptadine HCl was formulated. Spectrometric analysis of Cyproheptadine HCl was done by using UV-Visible spectrophotometer & Drug-Excipients compatibility study was conducted by FTIR. Oil, Surfactant, & Co-surfactant were selected based on the results of a solubility study for the formulation of Nanoemulsion, while the ratio of surfactant to co-surfactant (Smix) was determined through pseudo-ternary phase diagram study. 32 full Factorial Design was applied using Design Expert 13 software. Concentration of Oil (X1) & Concentration of Smix (X2) were chosen as independent variables, while Particle size (Y1) & Zeta potential (Y2) were selected as dependent variables. From the experimental design, NE7 batch containing 10% Capryol 90 & 60% Smix in 3:1 ratio of Tween 80: Transcutol P exhibited Particle size 132.9 nm & Zeta potential was -10.1 mV. Nanoemulgel prepared from Optimized Nanoemulsion showed great 94.75% Drug diffusion at 7 hr & it remained consistently stable over 1 month stability study. It is concluded that Nanoemulgel of Cyproheptadine HCl was formulated successfully.