Antihyperlipidemic Activity of Cinnamaldehyde in High-fat Diet-induced Hyperlipidemic Rat Model

Introduction: A rising blood lipid profile is known as hyperlipidemia. Untreated hyperlipidemia enhances the risk of atherosclerosis and cardiovascular disorders associated with mortality worldwide. This research evaluated the antihyperlipidemic and antioxidative effects of cinnamaldehyde in a high-fat diet-induced hyperlipidemic rat model. Methods: Sprague-Dawley albino rats of either sex (130-150g, 15-18 weeks old) were used in this study. Antihyperlipidemic activity of cinnamaldehyde (200 and 400 mg/kg/day, p.o.) and atorvastatin (10 mg/kg/day, p.o.) was assessed against a high-fat diet-induced hyperlipidemic rat model. After completion of the experimental protocol, the levels of total cholesterol, triglyceride, lowdensity lipoprotein, and high-density lipoprotein were measured in blood serum, and the levels of glutathione, superoxide dismutase, and malondialdehyde were measured in liver tissues. Results: The present study demonstrated the antihyperlipidemic effect of cinnamaldehyde on rats fed a high-fat diet, which includes the ability to restore plasma lipid levels. It also reduced the average body weight gain at the same time. Additionally, it increased GSH and SOD levels and decreased MDA levels. Discussion: The antihyperlipidemic activity of cinnamaldehyde might be due to its potent antioxidant level, which was observed in the present study. Conclusion: The present study concludes that cinnamaldehyde has potential antihyperlipidemic effects against hyperlipidemia.