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Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
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Structure of a sterol sensor
The aberrant accumulation of sterols contributes to heart attack and stroke. Two proteins embedded in the membrane of the endoplasmic reticulum, Insig-1 and Insig-2, are key players in the cellular pathway that regulates cellular sterol levels. Ren
et al.
report the structure of a mycobacterial homolog of Insig. The structure, together with biochemical experiments, suggests how Insig interacts with other components of the sterol regulatory pathway.
Science
, this issue p.
187
American Association for the Advancement of Science (AAAS)
Title: Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels
Description:
Structure of a sterol sensor
The aberrant accumulation of sterols contributes to heart attack and stroke.
Two proteins embedded in the membrane of the endoplasmic reticulum, Insig-1 and Insig-2, are key players in the cellular pathway that regulates cellular sterol levels.
Ren
et al.
report the structure of a mycobacterial homolog of Insig.
The structure, together with biochemical experiments, suggests how Insig interacts with other components of the sterol regulatory pathway.
Science
, this issue p.
187.
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