Sex Differences in Pain Catastrophizing and Its Relation to the Transition From Acute Pain to Chronic Pain

Abstract BACKGROUND AND IMPORTANCE Differences exist between sexes in pain and pain-related outcomes, such as development of chronic pain. Previous studies suggested a higher risk for pain chronification in female patients. Furthermore, pain catastrophizing is an important risk factor for chronification of pain. However, it is unclear whether sex differences in catastrophic thinking could explain the sex differences in pain chronification. OBJECTIVES The aim of this study was to examine sex differences in pain catastrophizing. Additionally, we investigated pain catastrophizing as a potential mediator of sex differences in the transition of acute to chronic pain. Design, settings and participants: Adults visiting one of the 15 participating emergency departments in the Netherlands with acute pain-related complaints. Subjects had to meet inclusion criteria and complete questionnaires about their health and pain (n = 1,906). OUTCOMES MEASURE AND ANALYSIS The outcomes in this prospective cohort study were pain catastrophizing (short form pain catastrophizing) and pain chronification at 90 days (Numeric Rating Scale ≥ 1). Data was analysed using univariate and multivariable logistic regression models. Finally, stratified regression analyses were conducted to assess whether differences in pain catastrophizing accounted for observed differences in pain chronification between sexes. MAIN RESULTS Females catastrophized pain significantly more than males (p<0.001). Multiple regression analyses suggested that pain catastrophizing is associated with pain chronification in both sexes, although significance was not reached in all groups. CONCLUSIONS This study reported differences between sexes in catastrophic cognitions in the development of chronic pain. This is of clinical importance to identify high-risk patients and ensure an early intervention to prevent the transition from acute to chronic pain.