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Negative Regulation of Wingless Signaling by D-Axin, a Drosophila Homolog of Axin
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Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of β-catenin/Armadillo, which in turn activates gene transcription. Here the
Drosophila
protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of
d-axin
resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of
d-axin
inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in
Drosophila
.
American Association for the Advancement of Science (AAAS)
Title: Negative Regulation of Wingless Signaling by D-Axin, a
Drosophila
Homolog of Axin
Description:
Wnt/Wingless directs many cell fates during development.
Wnt/Wingless signaling increases the amount of β-catenin/Armadillo, which in turn activates gene transcription.
Here the
Drosophila
protein D-Axin was shown to interact with Armadillo and D-APC.
Mutation of
d-axin
resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less.
Ectopic expression of
d-axin
inhibited Wingless signaling.
Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo.
These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in
Drosophila
.
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