Relationship of CYP17A1 Gene Selected Variants with Polycystic Ovary Syndrome

Objective: To analyze the SNP (Single nucleotide polymorphisms,) of the CYP17a1 gene in cases andcontrols and analyse the values of luteinizing hormone and follicle-stimulating hormone in females withPCOS and normal females.Material and Methods: The cross-sectional study was carried out at the Institute of Molecular Biology, TheUniversity of Lahore. After receiving ethical approval and informed consent, a sample of 120 participants (40PCOS, 40 aPCOS, and 40 Controls) was collected. The data was acquired via a questionnaire, and bloodsamples. Serum samples were PCR amplified for the CYP17a1 gene. The gathered data was analyzedgenomically and statistically with a probability of ≤ 0.05.Results: Mean ages in polycystic ovarian syndrome, aPCOS, and Controls were 22.68, 22.50, and 22.13years respectively. The CYP17a1 gene variant (10: rs743572 A/G) had an odds ratio of 1.18, signifying theoccurrence of the allele in both PCOS and normal females. Meanwhile, the odds ratio of 0.569 indicated thatthe allele is around 0.431 times less common in PCOS than in the Controls. .Conclusion: It was concluded that the CYP17a1 gene variant rs743572 was observed in both PCOS andnormal females. An insignificant association was found between the CYP17a1 gene disparity and PCOS.Keywords: Allele, CYP17a1, FSH, Genome, LH, PCOS.How to cite: Iftikhar SM, Lodhi MS, Mahmood M, Aamer R, Mughal AA, Ahmed SA. Relationship of CYP17A1Gene Selected Variants with Polycystic Ovary Syndrome. Esculapio - JSIMS 2025;22(01):DOI: 10.51273/esculap.v22i01.1402