Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Population studies of diphtheria immunity using antitoxin radioimmunoassay
View through CrossRef
SUMMARYA quantitative method for testing serum diphtheria antitoxin levels was set up using a diphtheria antitoxin radioimmunoassay (RIA). The results of this RIA correlated well with the Schick test in 554 subjects and with intradermal neutralization tests in guinea-pigs in a small group of subjects. The RIA was suitable for use on blood collected by fingerprick on to a disc of standard chromatography paper. These discs could be stored at room temperature for at least 1 month. If storage for more than 6 months was required –20 °C was found to be better. Experience with this RIA in a total of 2349 subjects indicated that it is more accurate, rapid and less costly than Schick testing. The RIA should prove to be the preferred method for testing diphtheria immunity in population surveys.
Title: Population studies of diphtheria immunity using antitoxin radioimmunoassay
Description:
SUMMARYA quantitative method for testing serum diphtheria antitoxin levels was set up using a diphtheria antitoxin radioimmunoassay (RIA).
The results of this RIA correlated well with the Schick test in 554 subjects and with intradermal neutralization tests in guinea-pigs in a small group of subjects.
The RIA was suitable for use on blood collected by fingerprick on to a disc of standard chromatography paper.
These discs could be stored at room temperature for at least 1 month.
If storage for more than 6 months was required –20 °C was found to be better.
Experience with this RIA in a total of 2349 subjects indicated that it is more accurate, rapid and less costly than Schick testing.
The RIA should prove to be the preferred method for testing diphtheria immunity in population surveys.
Related Results
Stability of the GraA Antitoxin Depends on Growth Phase, ATP Level, and Global Regulator MexT
Stability of the GraA Antitoxin Depends on Growth Phase, ATP Level, and Global Regulator MexT
ABSTRACTBacterial type II toxin-antitoxin systems consist of a potentially poisonous toxin and an antitoxin that inactivates the toxic protein by binding to it. Most of the toxins ...
Penyelidikan Epidemiologi Kejadian Luar Biasa (KLB) Difteri : Literatur Review
Penyelidikan Epidemiologi Kejadian Luar Biasa (KLB) Difteri : Literatur Review
Diphtheria is a type of infectious disease that can be prevented by immunization. The cause of diphtheria is toxigenic Corynebacterium diphtheriae strains. Humans are the only rese...
The Battle against Diphtheria: Nigeria's Ongoing Struggle
The Battle against Diphtheria: Nigeria's Ongoing Struggle
Abstract::
Corynebacterium diphtheriae is a Gram-positive, rod-shaped, nonmotile bacillus.
Lysogenic strains carry the diphtheria toxin gene (tox) on corynebacteriophages. It's cat...
PROFIL PENYAKIT DIFTERI, PENGETAHUAN, USIA, DAN RIWAYAT IMUNISASI PADA MASYARAKAT
PROFIL PENYAKIT DIFTERI, PENGETAHUAN, USIA, DAN RIWAYAT IMUNISASI PADA MASYARAKAT
ABSTRAKKasus difteri pada tahun 2018 kembali lagi ditemukan di Kabupaten Cianjur. Kejadian difteri tersebut dianggap suatu kasus Kejadian Luar Biasa (KLB) karena ditemukan sejumlah...
Re-emergence of diphtheria outbreak in Nigeria: Efforts, Challenges and Recommendations
Re-emergence of diphtheria outbreak in Nigeria: Efforts, Challenges and Recommendations
Diphtheria is a contagious and potentially fatal disease caused by Corynebacterium diphtheriae, a bacterium widely recognised for producing a potent exotoxin, and this disease has ...
Diphtheria in the WHO European Region, 2010 to 2019
Diphtheria in the WHO European Region, 2010 to 2019
Background
Diphtheria is uncommon in the World Health Organization (WHO) European Region. Nevertheless, sporadic cases, sometimes fatal, continue to be reported.
...
The Antitoxin Response of Schick-Negative Rheumatic and Non-Rheumatic Subjects to Diphtheria Toxoid
The Antitoxin Response of Schick-Negative Rheumatic and Non-Rheumatic Subjects to Diphtheria Toxoid
Summary
Nineteen Schick-negative children with rheumatic fever and 18 Schick-negative non-rheumatic children were given a booster dose of diphtheria toxoid subcutane...
Developing Burroughs Wellcome Alum-Toxoid
Developing Burroughs Wellcome Alum-Toxoid
Chapter four suggests that although the practical application of anti-diphtheria immunization in Cork achieved good results, its success was qualified somewhat by the limitations o...