DEVELOPMENT OF COMPOSITIONS AND TECHNOLOGY OF GELS CONTAINING PHYTOEXTRACTS

Relevance. Today, interest in the use of natural medicinal substances, medicinal products created on their basis and corresponding dosage forms continues to develop. This interest is associated with the unique properties of various phytocompositions, as well as with the intensive development of such classical sciences as biology, chemistry, and pharmacology. An urgent task is the development and introduction into production of original do-mestic dosage forms for external use, created on the basis of medicinal plant raw materials, which will solve the issues of successful pharmacother-apy for a number of diseases. The purpose of our research is to develop optimal compositions of gels based on Ginkgo biloba leaves and Rhodiola rosea rhizomes with roots of thick extracts, their biopharmaceutical studies in vitro for subsequent more in-depth pharmacotechnological studies. Material and methods. The object of our research is soft dosage forms developed on the basis of thick extracts of Ginkgo biloba leaves and Rho-diola rosea rhizomes with roots. Thick extracts were obtained by condensation in a rotary vacuum evaporator), into which the extracts and an alcohol-water-glycerin mixture 1:6:3 were placed. The ratio of thick extract and solvent mixture was 1:1. Mixing was carried out with a stirrer rotating no more than 30 rpm at room temperature until the mass was completely homogenized. The release of biologically active substances was studied by direct dif-fusion into agar and gelatin gels and by equilibrium dialysis through a semipermeable membrane. Results. Studies have shown that the most complete and rapid release of the active complex of the thick extract of Rhodiola rosea occurs from the Na-CMC base (TU 9199-001-07508109-2004). The highest degree of release of the active complex of the thick extract of Ginkgo biloba is observed from the chitosan base (TU 9289-067-00472124-03 Bioprogress LLC). Conclusions. In vitro biopharmaceutical studies were carried out to determine the level of release of the studied active substances of thick extracts of Rhodiola rosea rhizomes with roots and Ginkgo biloba leaves from various gel compositions, allowing to select the optimal composition of the dos-age form.