The relationship between endothelial activation and stress index with survival and early mortality in acute myeloid leukemia

Aim: The Endothelial Activation and Stress Index (EASIX) score is used as a marker of endothelial damage and used to predict acute graft-versus-host disease and sinusoidal obstruction syndrome. We wanted to evaluate the effects of EASIX, modified EASIX (mEASIX) and sepsis modified EASIX (sEASIX) on early mortality and overall survival (OS) in patients with acute myeloid leukemia. Materials and Methods: We reviewed patients diagnosed and followed up with Acute Myeloid Leukemia (AML) in our Hematology Department, retrospectively. Patients between 18 -70 years of age and who were administered 7+3 (7 days cytarabine, and 3 days anthracycline) chemotherapy protocol (except acute promyelocytic leukemia) were included. EASIX, mEASIX and sEASIX scores of the patients, both at the time of diagnosis and at the end of the 4th week, were calculated. Results: Seventy-five patients were included in the study. The mean age was 49.05 (19-68) years and 41% were alive. EASIX and mEASIX scores measured both at the time of diagnosis and at the end of induction therapy were found to be significantly associated with early mortality (p=0.01, p