Development of Sustained Release of Gatifloxacin by Using Floating Oral in Situ Gelling System

Gatifloxacin is end up being one of the potential medications against H. pylori infection. As conventional drug delivery systems do not remain in the stomach for delayed periods, they can't convey the Gatifloxacin to the site of infection in effective concentrations. Hence it planned to develop a new floating in situ gelling system of Gatifloxacin with increased residence time using sodium alginate as gelling polymer and HPMC as thickening agent with a potential of H. Pylori eradication. The formulations were evaluated on the basis of Pharmacopoeial specification. Clarity, visual appearance, pH, gelling capacity, viscosity, gelation, buoyancy, water uptake, density of gel, gel strength,  drug content, assessment of drug release, release kinetics were carried out as per specifications and results were found to be complied with the Pharmacopoeial specification. The formulation F6 shows good result as compared to other formulation. The findings of prepared in situ gelling formulations of Gatifloxacin increased the gastric residence time and also float in the gastric condition.