Effect of Helicobacter pylori enrichment in adenoma on clinical and pathological features of colorectal adenoma

Abstract Objective To observe the enrichment of Helicobacter pylori in adenoma tissues of patients with colorectal adenoma and analyze its effect on the clinical and pathological features of colorectal adenoma. Methods The data of 1622 cases of gastrointestinal endoscopy in the Endoscopy Center of Zhejiang Chinese Medical University Affiliated Wenzhou Hospital of Integrated Traditional Chinese and Western Medicine from January 2019 to June 2021 were retrospectively collected. The general data, gastric Hp infection, clinical and pathological features of colorectal adenoma, special staining of Hp methylblue in adenoma, and immunohistochemical staining of Hp in adenoma were compared between colorectal adenoma group (743 cases) and control group (879 cases). Results There were 361 cases (48.59%) of gastric Hp positive in colorectal adenoma group and 331 cases (37.66%) of gastric Hp positive in control group. The difference was significant (P < 0.001). Found that gastric Hp infection significantly increased the risk of Hp enrichment in colorectal adenoma tissues (OR: 28.449; 95% CI: 18.188 – 44.500; P < 0.001). Hp enrichment in colorectal adenomas was also found to be a contributing factor for positive events in terms of adenoma diameter, adenoma pathological type, and adenoma malignancy (OR: 3.536; 3.652; 2.833; P < 0.001 for all). Conclusion There is a positive correlation between gastric Hp infection and intestinal Hp enrichment. Intestinal Hp enrichment has a statistically significant effect on the clinical and pathological features of colorectal adenoma.