Nasal Bitter Taste Testing as A Screening Tool for Chronic Rhinosinusitis.

not-yet-known not-yet-known not-yet-known unknown Objectives. The expression and functionality of bitter taste receptors (T2Rs) in the sinonasal mucosa have been linked to variations in chronic rhinosinusitis (CRS) severity and susceptibility, suggesting a potential therapeutic target for managing this chronic condition. This study is aimed at developing a screening method to detect the bitter taste receptor in the nose and its sensitivity between healthy individuals and those with CRS using available bitter ligands therefore coming up with a suitable titration of this ligand for future use. Methods. A cross-sectional study of 84 adults (42 with chronic rhinosinusitis and 42 healthy controls) evaluated nasal glucose levels and phenylthiocarbamide (PTC) taste sensitivity. Colorimetric and statistical tests were used to analyse PTC threshold values and nasal glucose levels. Results. Based on 0.13% as the most suitable dilution for intranasal testing of PTC, there is an association between nasal bitter taste testing among CRS and control groups with a P value of <0.001. Conclusions. The bitter taste testing on the nose seems to be a simple and inexpensive way for screening patients with CRS. The titration and intranasal sites suggested in this study can be used as a basis for further prospective studies to view the outcome of patients with CRS. Targeting these receptors in diagnostic could open a new window of opportunity in the management of patients with CRS.