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Activation of PKC-alpha is required for migration of C6 glioma cells
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The PKC signaling pathway has been implicated in diverse cellular functions. Here, we sought to investigate the role of PKC-alpha/beta in C6 glioma cell migration. We found that both PKC-alpha and PKC-beta were expressed by C6 glioma cells, but only PKC-alpha was markedly activated in serum-treated C6 cells. Gö6976, a PKC-alpha/beta specific inhibitor, was found to cause a dose-dependent reduction of PKC-alpha activation and cell migration induced by serum in C6 cells. These results collectively indicated that the PKC-alpha signaling pathway is necessary for glioma cell migration. Our findings may provide an insight into a better understanding to the malignant progression of gliomas.
The Nencki Institute of Experimental Biology, Polish Academy of Sciences
Title: Activation of PKC-alpha is required for migration of C6 glioma cells
Description:
The PKC signaling pathway has been implicated in diverse cellular functions.
Here, we sought to investigate the role of PKC-alpha/beta in C6 glioma cell migration.
We found that both PKC-alpha and PKC-beta were expressed by C6 glioma cells, but only PKC-alpha was markedly activated in serum-treated C6 cells.
Gö6976, a PKC-alpha/beta specific inhibitor, was found to cause a dose-dependent reduction of PKC-alpha activation and cell migration induced by serum in C6 cells.
These results collectively indicated that the PKC-alpha signaling pathway is necessary for glioma cell migration.
Our findings may provide an insight into a better understanding to the malignant progression of gliomas.
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