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Urinary angiotensinogen in pediatric urinary tract infection
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AbstractBackgroundUrinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U‐AGT) is a new biomarker gathering attention in many renal diseases. U‐AGT reflects intrarenal renin–angiotensin system (RAS) activity. We conducted a study to measure U‐AGT in children <4 months old with UTI.MethodsAll children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included. Patients were divided into a UTI group and a non‐UTI group, and U‐AGT was measured.ResultsMedian U‐AGT was higher in patients with UTI compared with patients without UTI: (0.56 ng/dL, range, 0.025–2.753 ng/dL vs 0.13 ng/dL, range, 0.008–1.697 ng/dL, respectively; P < 0.05).ConclusionsU‐AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.
Title: Urinary angiotensinogen in pediatric urinary tract infection
Description:
AbstractBackgroundUrinary tract infection (UTI) is one of the most common diseases in children, and urinary angiotensinogen (U‐AGT) is a new biomarker gathering attention in many renal diseases.
U‐AGT reflects intrarenal renin–angiotensin system (RAS) activity.
We conducted a study to measure U‐AGT in children <4 months old with UTI.
MethodsAll children <4 months old who came to Toshima Hospital with fever between January 2015 and December 2015 were included.
Patients were divided into a UTI group and a non‐UTI group, and U‐AGT was measured.
ResultsMedian U‐AGT was higher in patients with UTI compared with patients without UTI: (0.
56 ng/dL, range, 0.
025–2.
753 ng/dL vs 0.
13 ng/dL, range, 0.
008–1.
697 ng/dL, respectively; P < 0.
05).
ConclusionsU‐AGT is elevated in UTI patients, and RAS activation may contribute to renal injury caused by UTI.
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