e0380 Associations between plasma N-terminal pro brain natriuretic peptide and oxidative stress in patients with chronic stable coronary artery disease

Objectives The present study was aimed to explore whether plasma N-terminal pro brain natriuretic peptide was associated with oxidative stress in patients with chronic stable coronary artery disease. Methods Plasma levels of N-terminal pro brain natriuretic peptide, hemeoxygenase-1 and oxidative low-density lipoprotein were determined by electrochemiluminescence and ELISA respectively in ninety-four patients with chronic stable coronary artery disease and 35 controls without coronary artery disease confirmed by coronary angiography. Correlations were analysed among these three biochemical marks. Results Logarithms-transformed levels of N-terminal pro brain natriuretic peptide and oxidative low-density lipoprotein in patients with chronic stable coronary artery disease were both higher than the controls (5.01±0.14 vs 3.73±0.16 Ln mg/l, p<0.001; 2.38±0.09 vs 0.09±0.13 Ln ug/l, p<0.001), whereas squart-root-transformed level of hemeoxygenase-1 was lower than the controls (6.10±0.24 vs 13.96±0.86 Sqrt ug/l, p<0.001). The difference in these three biochemical marks between the two groups was still in presence after being adjusted by age, sex, blood glucose, lipids and left ventricular ejection fraction. However, there wasn't difference in them in subgroup analysis by coronary artery lesion count. Logarithms-transformed levels of N-terminal pro brain natriuretic peptide and oxidative low-density lipoprotein were associated with each other positively (r=0.281, p<0.05), whereas logarithms-transformed level of N-terminal pro brain natriuretic peptide was correlated to squart-root-transformed level of hemeoxygenase-1 negatively (r=−0.277, p<0.05). Squart-root-transformed level of hemeoxygenase-1 was associated with logarithms-transformed level of oxidative low-density lipoprotein negatively (r=−0.575, p<0.001). After being adjusted by age, sex, blood glucose, lipids and left ventricular ejection fraction, logarithms-transformed level of N-terminal pro brain natriuretic peptide was still associated with logarithms-transformed level of oxidative low-density lipoprotein positively (r=0.269, p<0.05) and with squart-root-transformed level of hemeoxygenase-1 negatively (r=−0.261, p<0.05). Conclusions N-terminal pro brain natriuretic peptide was closely associated with oxidative stress in patients with chronic stable coronary artery disease. However the details of the interaction between brain natriurectic peptide and oxidative stress remain unknown.