The Relationship Of Polypharmacy With Glomerular Filtration Rate In Patients With Chronic Kidney Failure

Polypharmacy is generally used in hemodialysis patients with an average number of drugs given being 14 drugs. In addition to detecting and preventing the severity of renal function, hemodialysis can increase the glomerular filtration rate. This study aims to determine the relationship between polypharmacy and glomerular filtration rate in patients with chronic renal failure at RSUD Dr. Soegiri Lamongan. The research design uses design descriptive with method retrospective with data collection sheet instruments, the population in this study was 174 patients, the sample was selected using techniques purposive sampling By determining the inclusion criteria, 121 patients were obtained. Data analysis using tests Spearman Rho. The results of the number of drug use in chronic kidney failure patients showed that there were more major polypharmacy incidents of ?6 drugs, as many as 115 patients (95.04%). The glomerular filtration rate in patients is mostly in the range <15 ml/minute/1,73 m2 as many as 120 patients (99.17%). The results of data analysis show that there is no relationship between polypharmacy and glomerular filtration rate p 0.820. In theory, polypharmacy is related to a decrease in glomerular filtration rate, worsening the patient's condition, resulting in undesirable side effects and drug interactions. Polypharmacy with glomerular filtration rate will result in renal dysfunction and can further exacerbate multimorbidity, so that high levels of comorbidities and chronic inflammation can lead to worse clinical consequences.