Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Effect of Valsartan on Sarcoplasmic Reticulum Ca2+-ATPase Pump of the Left Ventricular Myocardium in Rats with Heart Failure with Preserved Ejection Fraction
View through CrossRef
<b><i>Objectives:</i></b> The aim was to investigate the effects of valsartan on the sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase pump (SERCA) and L-type Ca<sup>2+</sup> channel current (I<sub>CaL</sub>) of the left ventricular myocardium in rats with heart failure with preserved ejection fraction. <b><i>Methods:</i></b> The 30-week-old male spontaneously hypertensive rats (SHRs) are randomly divided into the non-Valsartan and Valsartan groups, and the 30-week-old male Wistar-Kyoto rats served as control rats. The expression of SERCA is measured by Western blot. The I<sub>CaL</sub> is measured by whole-cell patch clamp. The left ventricular end-diastolic pressure and left ventricular relaxation time constant quantity are measured at the same time. <b><i>Results:</i></b> The left ventricular end-diastolic pressure is much higher in SHRs compared with that in control rats (p < 0.01). The left ventricular relaxation time constant quantity is markedly extended in SHRs compared with control rats (p < 0.01). Valsartan cannot increase the expression of SERCA nor decrease the density of I<sub>CaL</sub> compared with the non-Valsartan group (p > 0.05). <b><i>Conclusions:</i></b> Valsartan has no effect on SERCA and I<sub>CaL</sub> of the left ventricular myocardium in rats with heart failure with preserved ejection fraction.
Title: Effect of Valsartan on Sarcoplasmic Reticulum Ca2+-ATPase Pump of the Left Ventricular Myocardium in Rats with Heart Failure with Preserved Ejection Fraction
Description:
<b><i>Objectives:</i></b> The aim was to investigate the effects of valsartan on the sarcoplasmic reticulum Ca<sup>2+</sup>-ATPase pump (SERCA) and L-type Ca<sup>2+</sup> channel current (I<sub>CaL</sub>) of the left ventricular myocardium in rats with heart failure with preserved ejection fraction.
<b><i>Methods:</i></b> The 30-week-old male spontaneously hypertensive rats (SHRs) are randomly divided into the non-Valsartan and Valsartan groups, and the 30-week-old male Wistar-Kyoto rats served as control rats.
The expression of SERCA is measured by Western blot.
The I<sub>CaL</sub> is measured by whole-cell patch clamp.
The left ventricular end-diastolic pressure and left ventricular relaxation time constant quantity are measured at the same time.
<b><i>Results:</i></b> The left ventricular end-diastolic pressure is much higher in SHRs compared with that in control rats (p < 0.
01).
The left ventricular relaxation time constant quantity is markedly extended in SHRs compared with control rats (p < 0.
01).
Valsartan cannot increase the expression of SERCA nor decrease the density of I<sub>CaL</sub> compared with the non-Valsartan group (p > 0.
05).
<b><i>Conclusions:</i></b> Valsartan has no effect on SERCA and I<sub>CaL</sub> of the left ventricular myocardium in rats with heart failure with preserved ejection fraction.
Related Results
Hydatid Disease of The Brain Parenchyma: A Systematic Review
Hydatid Disease of The Brain Parenchyma: A Systematic Review
Abstarct
Introduction
Isolated brain hydatid disease (BHD) is an extremely rare form of echinococcosis. A prompt and timely diagnosis is a crucial step in disease management. This ...
Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake
Computational analysis of Ca2+ dynamics in isolated cardiac mitochondria predicts two distinct modes of Ca2+ uptake
Key points
Cytosolic, but not matrix, Mg2+ inhibits mitochondrial Ca2+ uptake through the Ca2+ uniporter (CU).
The majority of mitochondrial Ca2+ uptake under physiological levels ...
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis
Calcium/Calmodulin Protein Kinase II-Dependent Ryanodine Receptor Phosphorylation Mediates Cardiac Contractile Dysfunction Associated With Sepsis
Objectives:
Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca2+ handling. We examined the subcellular mechanisms involved in sar...
Efficacy and safety of vericiguat in patients with HFrEF treated with sacubitril/valsartan: results from the VICTORIA trial
Efficacy and safety of vericiguat in patients with HFrEF treated with sacubitril/valsartan: results from the VICTORIA trial
Abstract
Background
In the VICTORIA trial (n=5050) the reduction in the primary composite endpoint of cardiovascular death (CVD)...
Comparative and Combinatorial Effects of Resveratrol and Sacubitril/Valsartan alongside Valsartan on Cardiac Remodeling and Dysfunction in MI-Induced Rats
Comparative and Combinatorial Effects of Resveratrol and Sacubitril/Valsartan alongside Valsartan on Cardiac Remodeling and Dysfunction in MI-Induced Rats
The development and progression of heart failure (HF) due to myocardial infarction (MI) is a major concern even with current optimal therapy. Resveratrol is a plant polyphenol with...
Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes
Protein carbonylation causes sarcoplasmic reticulum Ca2+ overload by increasing intracellular Na+ level in ventricular myocytes
Abstract
Diabetes is commonly associated with an elevated level of reactive carbonyl species due to alteration of glucose and fatty acid metabolism. These metabolic changes...
Mechanism of Ca2+Transport by Sarcoplasmic Reticulum
Mechanism of Ca2+Transport by Sarcoplasmic Reticulum
AbstractThe sections in this article are:Structure of Sarcoplasmic Reticulum and Transverse TubulesStructure of Plasmalemma and T TubulesSarcoplasmic ReticulumJunction Between T Tu...
Na+/Ca2+ exchange current in ventricular myocytes of fish heart: contribution to sarcolemmal Ca2+ influx
Na+/Ca2+ exchange current in ventricular myocytes of fish heart: contribution to sarcolemmal Ca2+ influx
ABSTRACT
Influx of extracellular Ca2+ plays a major role in the activation of contraction in fish cardiac cells. The relative contributions of Na+/Ca2+ exchange and ...