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Enantioselective Chromatographic Analysis of Formoterol Fumarate using Chiral Mobile Phase Additives and Achiral Core-Shell Column
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A
simple, robust, cost-effective, and rapid RP-HPLC method was developed for the
separation of enantiomers of formoterol. The separation was achieved by the chiral
mobile phase additive technique on an achiral column. Formoterol is a bronchodilator
that consists of 50:50 S, S-formoterol and R, R-formoterol. The bronchodilator
activity is attributed to R, R-formoterol. Hence, it is important to develop a method
to separate the enantiomers of formoterol. Various factors affecting
enantiomeric resolution were investigated and optimized. The enantiomers of
formoterol were successfully separated with a resolution of 2.57 with a
run-time of 9 minutes. The method was validated in accordance with ICH
guidelines. The validated
method was successfully applied to the marketed formulation of arformoterol.
Title: Enantioselective Chromatographic Analysis of Formoterol Fumarate using Chiral Mobile Phase Additives and Achiral Core-Shell Column
Description:
A
simple, robust, cost-effective, and rapid RP-HPLC method was developed for the
separation of enantiomers of formoterol.
The separation was achieved by the chiral
mobile phase additive technique on an achiral column.
Formoterol is a bronchodilator
that consists of 50:50 S, S-formoterol and R, R-formoterol.
The bronchodilator
activity is attributed to R, R-formoterol.
Hence, it is important to develop a method
to separate the enantiomers of formoterol.
Various factors affecting
enantiomeric resolution were investigated and optimized.
The enantiomers of
formoterol were successfully separated with a resolution of 2.
57 with a
run-time of 9 minutes.
The method was validated in accordance with ICH
guidelines.
The validated
method was successfully applied to the marketed formulation of arformoterol.
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