MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma

Abstract Objective: To assess MRI apparent diffusion coefficient as potential biomarkers in the diagnosis of osteosarcoma. Methods: 94 patients with osteosarcoma confirmed by surgical pathology in our hospital from September 2019 to September 2021 were selected as the research objects. All the research objects underwent magnetic resonance diffusion weighted imaging and multi-slice spiral CT. The results of surgical pathology were used as the comparison standard. The apparent diffusion coefficient and image signs of multi-slice spiral CT in all patients were analyzed, and the application value of MRI apparent diffusion coefficient combined with multi-slice spiral CT in differentiating osteosarcoma was analyzed by area under curve (AUC) of receiver operating characteristics (ROC). Results: after treatment, the ADC value of the two groups was significantly higher than that before treatment, and the ADC value of the effective group was significantly higher than that of the ineffective group (P < 0.05); The coincidence rate of combined diagnosis was 97.26%, which was significantly higher than that of ADC and MSCT (P<0.05); The diagnostic efficacy of combined diagnosis of benign and malignant osteosarcoma was: sensitivity 95.61%, specificity 86.52%, accuracy 93.67%, positive detection rate 96.39%, negative detection rate 86.44%. The diagnostic efficacy of combined diagnosis was significantly higher than that of single diagnosis (P<0.05). The area under ROC curve AUC of combined diagnosis of benign and malignant osteosarcoma was 0.861 (95% CI: 0.853 ~ 0.948); In the combined diagnosis results, 62 cases (87.33), 2 cases (2.82), 1 case (1.41), 1 case (1.41), 1 case (1.41), 3 cases (5.63), 1 case (1.41) and 2 cases (2.82) were common type, 2 cases (2.82) were intramedullary well differentiated type, 1 case (1.41) of high-grade bone surface type, 3 cases (5.63), 1 case (1.41) of periosteal type and 2 cases (2.82) of paracortical type. The coincidence rate of the combined diagnosis results was significantly higher than that of ADC and MSCT (P; The accuracy of ADC value combined with MSCT in the diagnosis of different types of osteosarcoma was 100.00%, 100.00%, 50.00%, 100.00%, 100.00% and 100.00% respectively, which was partially higher than that of single diagnosis (P<0.05). Conclusion: MRI apparent diffusion coefficient combined with multi-slice spiral CT in the diagnosis of osteosarcoma has high sensitivity and specificity, can significantly improve the clinical diagnostic efficiency, and provide reference materials for the diagnosis and treatment of osteosarcoma.