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Advancements in misfolded prion protein detection
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Prion diseases are fatal, progressive, transmissible neurodegenerative
conditions that affect both humans and animals. The scrapie prion
protein (PrPSc), a misfolded form of prion, is both the cause of prion
diseases and gold standard biomarker for diagnosis. Given the
infectivity and 100% lethality of prions, new detection methods are
urgently needed to enhance the diagnosis and surveillance of prion
diseases. In this review, we summarize recent advancements in PrPSc
detection. We explore in vitro seeding assays, such as Protein
Misfolding Cyclic Amplification and Real-Time Quaking-Induced
Conversion, alongside innovative biosensors and imaging techniques
developed for prion detection. This review highlights the evolving
landscape of PrPSc detection methods and their potential roles in early
diagnosis, prion transmission control, and effective treatment
development.
Title: Advancements in misfolded prion protein detection
Description:
Prion diseases are fatal, progressive, transmissible neurodegenerative
conditions that affect both humans and animals.
The scrapie prion
protein (PrPSc), a misfolded form of prion, is both the cause of prion
diseases and gold standard biomarker for diagnosis.
Given the
infectivity and 100% lethality of prions, new detection methods are
urgently needed to enhance the diagnosis and surveillance of prion
diseases.
In this review, we summarize recent advancements in PrPSc
detection.
We explore in vitro seeding assays, such as Protein
Misfolding Cyclic Amplification and Real-Time Quaking-Induced
Conversion, alongside innovative biosensors and imaging techniques
developed for prion detection.
This review highlights the evolving
landscape of PrPSc detection methods and their potential roles in early
diagnosis, prion transmission control, and effective treatment
development.
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