Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
The Influence of Cyclodextrin and pH on the Solubility of Ketoprofen
View through CrossRef
Cyclodextrin complexation and pH adjustments have been reported as useful tools to increase the solubility of drug. The aim of this study was to investigate the influence of both cyclodextrin and pH on the overall solubility of ketoprofen. β-cyclodextrin (β-CD) and hydroxypropyl β-cyclodextrin (HP-β-CD) were used for the preparation of inclusion complex by shaking method in aqueous solution at pH 2, 5, 7 and 10. It was found that the solubility of ketoprofen significantly increased with increasing pH and cyclodextrin concentration, showing AL type phase solubility diagram. However, the apparent stability constant of complex (KC) was found to decrease with increasing pH due to the decreased affinity of ionized drug to cyclodextrin cavity. The ionization of ketoprofen increased when the pH was raised, corresponding with its higher zeta potential. The result indicated that the solubility of ketoprofen could be improved by using a combined approach of pH adjustments and complexation with cyclodextrin. Moreover, the unionized drug that was formed by pH adjustments interacted with cyclodextrin more strongly than the ionized drug.
Trans Tech Publications, Ltd.
Title: The Influence of Cyclodextrin and pH on the Solubility of Ketoprofen
Description:
Cyclodextrin complexation and pH adjustments have been reported as useful tools to increase the solubility of drug.
The aim of this study was to investigate the influence of both cyclodextrin and pH on the overall solubility of ketoprofen.
β-cyclodextrin (β-CD) and hydroxypropyl β-cyclodextrin (HP-β-CD) were used for the preparation of inclusion complex by shaking method in aqueous solution at pH 2, 5, 7 and 10.
It was found that the solubility of ketoprofen significantly increased with increasing pH and cyclodextrin concentration, showing AL type phase solubility diagram.
However, the apparent stability constant of complex (KC) was found to decrease with increasing pH due to the decreased affinity of ionized drug to cyclodextrin cavity.
The ionization of ketoprofen increased when the pH was raised, corresponding with its higher zeta potential.
The result indicated that the solubility of ketoprofen could be improved by using a combined approach of pH adjustments and complexation with cyclodextrin.
Moreover, the unionized drug that was formed by pH adjustments interacted with cyclodextrin more strongly than the ionized drug.
Related Results
Formulation and In Vitro Evaluation of Matrix Tablets Containing Ketoprofen–Beta Cyclodextrin Complex for Enhanced Rheumatoid Arthritis Therapy: Experimental and Computational Insights
Formulation and In Vitro Evaluation of Matrix Tablets Containing Ketoprofen–Beta Cyclodextrin Complex for Enhanced Rheumatoid Arthritis Therapy: Experimental and Computational Insights
Background: Rheumatoid arthritis is a chronic autoimmune disease that leads to severe disability and requires improved therapeutic strategies to optimize anti-inflammatory treatmen...
Preparation and Characterization of Flurbiprofen/β-Cyclodextrin Inclusion Complex
Preparation and Characterization of Flurbiprofen/β-Cyclodextrin Inclusion Complex
This study aims to ameliorate the water solubility of flurbiprofen by using β-cyclodextrin (β-CD). The drug/ligand 1:1 (M/M) stoichiometry was determined based on the effect of β-C...
Pengaruh Konsentrasi Gelling Agent dan Ratio Fase Minyak Dan Surfaktan Terhadap Formulasi Gel Mikroemulsi Ketoprofen
Pengaruh Konsentrasi Gelling Agent dan Ratio Fase Minyak Dan Surfaktan Terhadap Formulasi Gel Mikroemulsi Ketoprofen
Ketoprofen adalah obat golongan anti inflamasi non steroid yang dibuat dalam gel mikroemulsi untuk meminimalkan efek samping gastrointestinal. Penelitian ini bertujuan untuk menget...
Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal
Ketoprofen as an emerging contaminant: occurrence, ecotoxicity and (bio)removal
Ketoprofen, a bicyclic non-steroidal anti-inflammatory drug commonly used in human and veterinary medicine, has recently been cited as an environmental contaminant that raises conc...
Study on the Inclusion Mechanism of Sarafloxacin/β-cyclodextrin Inclusion Complex
Study on the Inclusion Mechanism of Sarafloxacin/β-cyclodextrin Inclusion Complex
Abstract
The purpose of this study is to explore the inclusion mechanism of sarafloxacin/β- cyclodextrin inclusion complex and explain the fundamental reasons for the impro...
Penentuan Kadar Ketoprofen Generik Dan Nama Dagang Dengan Metode Spektrofotometri-UV
Penentuan Kadar Ketoprofen Generik Dan Nama Dagang Dengan Metode Spektrofotometri-UV
Ketoprofen is a non-steroidal anti-inflammatory drug that is used to reduce pain due to inflammation in various rheumatic conditions and degenerative disorders of the skeletal musc...
Simvastatin dengan Senyawa Turunan Β-Siklodextrin
Simvastatin dengan Senyawa Turunan Β-Siklodextrin
This study aims to determine the profile of the inclusion complex formed between simvastatin and β-cyclodextrin and its derivatives. To determine the level of stability and determi...
Ketoprofen: The European Experience
Ketoprofen: The European Experience
An overview of European experience with ketoprofen, a nonsteroidal anti‐inflammatory drug (NSAID) with analgesic properties, from the time of its marketing in 1973 until the presen...