İkinci-dördüncü parmak oranının hayat boyu erken boşalma ile ilişkisi

OBJECTIVE: The second and fourth finger ratio (2D: 4D) is accepted as an indicator of fetal androgen exposure, and it is stated that the androgenic effect exposed during the fetal period may be related to premature ejaculation. In this study, it was aimed to investigate the relationship between prenatal androgen exposure and lifelong premature ejaculation using 2D: 4D. MATERIAL and METHODS: The data of 146 patients with lifelong premature ejaculation and 183 patients without any sexual complaints were compared. Detailed history, demographic data, and self-estimated intravaginal ejaculation times were recorded. 2D: 4D measurements of both hands were made and compared with the control group. Ejaculation function was evaluated with the Premature Ejaculation Diagnostic Tool, and erectile function was evaluated with the International Erectile Function Index. RESULTS: The 2D: 4D measurements in the premature ejaculation and control groups were 0.971±0.017 and 0.978±0.019 (p=0.001) for the right hand, and 0.973±0.017 vs. 0.976±0.018 (p=0.087) for the left hand, respectively. There was a significant relationship between finger ratios and self-estimated intravaginal ejaculation times (for right hand; r=0.980, p= <0.001; for left hand; r=0.984, p= <0.001) and total Premature Ejaculation Diagnostic Tool scores (for right hand; r=-0.982, p= <0.001; For left hand; r=-0.979, p= <0.001). CONCLUSION: A lower 2D: 4D ratio was associated with shorter intravaginal ejaculation latency times. The findings suggested that increased fetal androgen exposure may be a risk factor for lifelong premature ejaculation. Keywords: fetal androgen, premature ejaculation, 2D:4D ratio, anthropometric measurements, premature ejaculation diagnostic tool, intravaginal ejaculation latency times