On the structure of expansine, a bactericidal and fungicidal substance in penicillium expansum westl.

AbstractFrom this investigation it is concluded that expansine C7H6O4, a substance with bactericidal and fungicidal properties isolated by Oosterhuis and Luyken ) H. K. Oosterhuis and R. Luyken, unpublished work. ) from the culture liquid of Penicillium expansum Westl., very probably has the structure of an anhydro‐3‐hydroxymethylene‐tetrahydro‐γ‐pyron‐2‐carboxylic acid.Expansine is probably identical with patulin ) Patulin: H. Raistrick, J. H. Birkenshaw, A. Bracken, W. E. Gye, W. A. Hopkins and M. Greenwood, Lancet 245, 625–634 (1943). E. Chain, Brit. Med. Bull. 2, 1 (1944). Article in Brit. Med. J. 27/11/1943, p. 683. C. H. Stuart Harris, E. Francis and J. M. Staufeld, Lancet 245, 684 (1943). E. Chain, H. W. Florey, M. A. Jennings, D. Crowfoot and B. Low, Lancet 246, 112 (1944), Compt. rend. 1944 II. 25. I. R. Hooper, H. W. Anderson, P. Skell and H. E. Carter, Science (New York) 99, 16 (1944), Compt. rend. 1944 II. 25. Kenneth Walker and B. P. Wiesner, Lancet 246, 294 (1944), Compt. rend. 1944 II, 25. Schweiz. Med. Wochschr. 74, 611—636 (1944). Renseignements scientifiques d'hygiène, médicine et biologie no. 2, 44 (1944). Nachrichten für Aussenhandel Nr. 134 (1944). Chemie 57, 79 (1944). ), claviformin ) Claviformin: Wilkins and Harris, J. Exptl. Path. 23, 166 (1942). E. Chain, H. W. Florey and H A. Jennings loc. cit. E. Chain, H. W. Florey, A. D. Gardner, N. G. Heatley, M. A. Jennings, J. Orr Ewing and A. G. Sanders, Lancet 242, 226 (1940). ) and clavacin ) Clavacin: G. A. Glister, Nature 148, 470 (1941). B. P. Wiesner. Nature 149, 356 (1941). I. R. Hooper, H. W. Anderson, P. Skell and H. E. Garter loc. cit. Kenneth Walker and B. P. Wiesner loc. cit. Waksman and Horning‐Spencer, J. Bact. 45, 233 (1943). ).