Comparison of domeperidone versus metoclopramide to increase the milk production in lactating mothers.

Objective: To compare domeperidone and metoclopramide to increase the milk production in lactating mothers. Study Design: Randomized Controlled Trial. Setting: Department of Gynecology and Obstetrics, Sheikh Zayed Hospital, Rahim Yar Khan. Period: February 2021 to August 2021. Material & Methods: A total of 190 lactating mothers within 1 month of delivery and milk production less than 160 ml/kg/day were included. Women in Group-A were given metoclopramide in a dose of 10 mg three times a day in oral form and those in Group-B were given tablet domeperidone in the same dose and protocol. These women were then followed up and assessed at day-10 regarding the milk production over the previous 24 hours. Treatment compliance was also noted. Results: In a total of 190 women, the mean age was 29.86±5.49 years ranging between 20-40 years. Majority of the women, 114 (65.3%) were aged between 31-40 years. The mean weight was 71.78±8.75 kg while the mean parity was 2.32±1.06. Pre-treatment mean milk production was 159.43±89.67 ml in metoclopramide group versus 157.98±78.59 ml in domperidone group (p=0.9058). After 10 days of treatment, mean milk production was noted to be 183.61±31.44 ml in metoclopramide versus 245.63±68.84 ml in domperidone and the difference was noted to be significant favoring domperidone group (p<0.0001). Treatment compliance was statistically similar in both treatment groups (58.2% vs. 64.4%, p=0.4617). Conclusion: Domperidone is better in increasing the milk production in lactating mothers as compared to metoclopramide.