Diagnostic Value of LGE and T1 mapping in Multiple Myeloma patients’heart

Abstract Background Unidentified heart failure occurs in patients with multiple myeloma when their heart was involved. CMR with late gadolinium enhancement (LGE) and T1 mapping can identify myocardial amyloid infiltrations. Purpose To explore the role of CMR with late gadolinium enhancement (LGE) and T1 mapping for detection of multiple myeloma patients’heart. Material and Methods A total of 16 MM patients with above underwent CMR (3.0-T) with T1 mapping (pre-contrast and post-contrast) and LGE imaging. In addition, 26 patients with non-obstructive hypertrophic cardiomyopathy and 26 healthy volunteers were compared to age- and sex-matched healthy controls without a history of cardiac disease, diabetes mellitus, or normal in CMR. All statistical analyses were performed using the statistical software GraphPad Prism. The measurement data were represented by median (X) and single sample T test was adopted. Enumeration data were represented by examples and tested was adopted. All tests were two-sided, and P values < 0.05 were considered statistically significant. Results In MM group, LVEF was lower than healthy controls and higher than that of non-obstructive hypertrophic cardiomyopathy group, but without statistically significant difference ((%: 49.1 ± 17.5 vs. 55.6 ± 10.3、40.4 ± 15.6, all P > 0.05). Native T1 values of MM group were obviously higher than those of healthy controls and non-obstructive hypertrophic cardiomyopathy group (ms:1462.0 ± 71.3vs. 1269.3 ± 42.3、1324.0 ± 45.1, all P < 0.05). 16 cases (100%) in MM group all had LGE. Conclusion LGE joint T1 mapping examination can improve diagnostic accuracy and is extremely meaningful for patient diagnosis and follow-up.