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Persistent Nav1.6 current drives spinal locomotor functions through nonlinear dynamics
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Summary
Persistent sodium current (
I
NaP
) in the spinal locomotor network promotes two distinct nonlinear firing patterns: a self-sustained spiking triggered by a brief excitation in bistable motoneurons and bursting oscillations in interneurons of the central pattern generator (CPG). Here, we identified the NaV channels responsible for
I
NaP
and their role in motor behaviors. We report the axonal
Nav1.6
as the main molecular player for
I
NaP
in lumbar motoneurons. The motoneuronal inhibition of
Nav1.6
, but not of
Nav1.1
, impairs
I
NaP
, bistability, postural tone and locomotor performance. In interneurons of the CPG region,
Nav1.6
with
Nav1.1
equally mediate
I
NaP
and the inhibition of both channels is required to abolish oscillatory bursting activities and the locomotor rhythm. Overall,
Nav1.6
plays a significant role both in posture and locomotion by governing
I
NaP
-dependent bistability in motoneurons and working in tandem with
Nav1.1
to provide
I
NaP
-dependent rhythmogenic properties of the CPG.
Title: Persistent Nav1.6 current drives spinal locomotor functions through nonlinear dynamics
Description:
Summary
Persistent sodium current (
I
NaP
) in the spinal locomotor network promotes two distinct nonlinear firing patterns: a self-sustained spiking triggered by a brief excitation in bistable motoneurons and bursting oscillations in interneurons of the central pattern generator (CPG).
Here, we identified the NaV channels responsible for
I
NaP
and their role in motor behaviors.
We report the axonal
Nav1.
6
as the main molecular player for
I
NaP
in lumbar motoneurons.
The motoneuronal inhibition of
Nav1.
6
, but not of
Nav1.
1
, impairs
I
NaP
, bistability, postural tone and locomotor performance.
In interneurons of the CPG region,
Nav1.
6
with
Nav1.
1
equally mediate
I
NaP
and the inhibition of both channels is required to abolish oscillatory bursting activities and the locomotor rhythm.
Overall,
Nav1.
6
plays a significant role both in posture and locomotion by governing
I
NaP
-dependent bistability in motoneurons and working in tandem with
Nav1.
1
to provide
I
NaP
-dependent rhythmogenic properties of the CPG.
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