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Ring-Opening Fluorination of Isoxazoles
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A ring-opening fluorination of isoxazoles has been developed. By treating isoxazoles with an electrophilic fluorinating agent (Selectfluor®), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds. The present method features mild reaction conditions, good functional group tolerance, and simple experimental procedure. Diverse transformations of the resulting α-fluorocyanoketones were also demonstrated, furnishing a variety of fluorinated compounds.
American Chemical Society (ACS)
Title: Ring-Opening Fluorination of Isoxazoles
Description:
A ring-opening fluorination of isoxazoles has been developed.
By treating isoxazoles with an electrophilic fluorinating agent (Selectfluor®), fluorination followed by deprotonation leads to tertiary fluorinated carbonyl compounds.
The present method features mild reaction conditions, good functional group tolerance, and simple experimental procedure.
Diverse transformations of the resulting α-fluorocyanoketones were also demonstrated, furnishing a variety of fluorinated compounds.
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