Studies on the Liberation of Renin in completely Ischemic Kidneys.

Summary. A review is given of previous investigations into the liberation of renin from totally ischemic kidneys, and it is confirmed that a pressor effect can be obtained on the termination of the temporary total occlusion of the renal vessels in cats. It is shown that a liberation of pressor substance after total occlusion of the renal vessels can be obtained also in rabbits, and that pressor substance is found also in perfusates of cat and rabbit kidneys incubated in Ringer's solution. In perfusates of rabbit kidneys immediately after extirpation, no, or scarcely any, pressor substance is observed; but after incubation at ca. 2“ C. some pressor substance is found, and after incubation at 37” considerably more, with a tendency to increase in amount according to the duration of the incubation. It is shown that the content of pressor substance in perfusates of incubated rabbit kidneys is considerably increased (is approximately 5–10 doubled) after pre‐treatment of the kidneys with phenol, toluol, ether or acetone. The pressor substance in these perfusates must be considered to be identical with renin.