DESIGN AN “IN-HOUSE” SOFTWARE FOR CALCULATING THE RISK OF TRISOMY 21, TRISOMY 18 AND OPEN NEURAL TUBE DEFECTS IN THE GESTATIONAL AGED 15 – 22 WEEKS

Objectives: Design an “in-house” software for calculating the risk of fetus has Down syndrome, Edwards syndrome and open neural tube defects in prenatal screening at the gestational aged 15-22. Methods: Based on the Excel program of Microsoft Office and the articles with the Excel of Microsoft Office and related published articles, we design an “in-house” software based on maternal age, gestational age, history of having children with chromosomal aberrations and adjusted maternal serum markers AFP, hCG and uE3. The results were compared with the results of Prisca software by non-parametric method. Results: In cases having the risk of trisomy 21 with the range from 1/251 to 1/350: the risk tends to be lower than Prisca (83.7%). In cases having the high risks of trisomy 21 in screening but the results of prenatal diagnosis are not trisomy: the risks of “in house” software are lower than the risks of Prisca (73%) with 29% of cases has the risks less than 1/250 . In cases of trisomy 18 with the risks are lower than 1/150: there are no statistical significant differences between the two softwares (P<0.05). In screening open neural tube defects, the cases have the threshold higher than 1.50 MoM AFP: The results in the “in house” software tend to higher than Prisca (94%). The cases have the threshold lower than 1.50 MoM AFP: Where the disability screening of neural tube openings with thresholds lower than 1.5 MoM AFP: there are no statistical significant differences between the two softwares (P<0.05). Conclusion: The “in house” software has all the necessary functions for calculating the risk of Down syndrome, Edwards syndrome and open neural tube at the gestational aged 15-22.