EVALUATION OF SKELETAL MUSCLE RELAXANT ACTIVITY OF PIPER BETEL IN MICE

Objective: To evaluate skeletal muscle relaxant of Ethanolic extracts of Piper betel leaves in albino mice by using rota rod method and Inclined plane model. Methods: Healthy, adult Swiss albino mice of either sex weighing (25-40 g), maintained under standard laboratory conditions, at temperature 25±2 °C and a 12 h light-12 h dark period employed for the experimentation. Food and water provided ad libitum. Skeletal muscle activity animal model: The behavioral effects of an acute or sub-acute (10 d course) orally administered. “Piper betel” (250 and 500 mg/kg) ethanolic extract of leaves evaluated in male/female Swiss mice by rota rod Method and Inclined Plane Model (IPM). The effects of diazepam (DZP; 4 mg/kg) also assessed by Rota rod method and Inclined plane model. Results: In the present study, the skeletal muscle relaxant activity of ethanolic extract of Piper betel in Swiss albino mice, at the dose of 250 and 500 mg/kg with oral administration respectively. Conclusion: In conclusion both the doses of 250 and 500 mg/kg with oral administration have shown significant results as skeletal muscle relaxant effect using Rota rod method and Inclined plane model.