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The role of CD36 in cardiovascular diseases
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CD36, also known as scavenger receptor B2, is a multifunctional receptor
widely expressed in various organs. CD36 plays a crucial role in the
uptake of long-chain fatty acids, the main metabolic substrate in
myocardial tissue. The maturation and transportation of CD36 was
regulated by the post-translational modifications including
phosphorylation, ubiquitination, glycosylation, and palmitoylation. CD36
is decreased in pathological cardiac hypertrophy caused by
ischemia-reperfusion and pressure overload, while increased in diabetic
cardiomyopathy. Deficiency of CD36 alleviate diabetic cardiomyopathy,
while overexpression of CD36 eliminates the damage of
ischemia-reperfusion, suggesting that CD36 is closely associated with
the progression of cardiovascular diseases. and it is expected to be a
new therapeutic target. This review summarizes the regulation and
post-translational modifications of CD36, and evaluates its role in main
cardiovascular diseases and its potential as a therapeutic target.
Title: The role of CD36 in cardiovascular diseases
Description:
CD36, also known as scavenger receptor B2, is a multifunctional receptor
widely expressed in various organs.
CD36 plays a crucial role in the
uptake of long-chain fatty acids, the main metabolic substrate in
myocardial tissue.
The maturation and transportation of CD36 was
regulated by the post-translational modifications including
phosphorylation, ubiquitination, glycosylation, and palmitoylation.
CD36
is decreased in pathological cardiac hypertrophy caused by
ischemia-reperfusion and pressure overload, while increased in diabetic
cardiomyopathy.
Deficiency of CD36 alleviate diabetic cardiomyopathy,
while overexpression of CD36 eliminates the damage of
ischemia-reperfusion, suggesting that CD36 is closely associated with
the progression of cardiovascular diseases.
and it is expected to be a
new therapeutic target.
This review summarizes the regulation and
post-translational modifications of CD36, and evaluates its role in main
cardiovascular diseases and its potential as a therapeutic target.
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