Protective effects of Moringa oleifera seed Extracts on Nutmeg induced Kidney Toxicity in Wistar Rats

Nutmeg is a popular household spices that has a serious health effect when abused, and has been found to have a very serious toxic effects on the kidney. This study investigated the protective potency of Moringa oleifera seed extracts on nutmeg induced nephrotoxicity. This study made use of twenty-four (24) Wistar rats weighing between 80-150g, which was randomly selected into six groups. Group A received no treatment while Group B was administered 500 mg/kg of nutmeg seed extract. Group C received 500 mg/kg of nutmeg seed extract and 200mg/kg of moringa ethanolic seed extract. Group D was administered 500 mg/kg of nutmeg seed extract and 400mg/kg of moringa ethanolic seed extract. Group E was administered 500 mg/kg of nutmeg seed extract and 200mg/kg of moringa n-hexane seed extract. Group F was also administered 500 mg/kg of nutmeg seed extract and 400mg/kg of moringa n-hexane seed extract. From the histological analysis, the photomicrographs of groups B, C and E showed significant renal damage, while groups A, D and F showed normal kidney histoarchitecture with intact glomeruli and convoluted tubules.The results from this study confirmed the protective potency of Moringa on nutmeg induced kidney toxicity at the histological level. However, further research is encouraged. Keywords: Nutmeg Toxicity, Nephrotoxicity, Moringa oleifera, Kidney Damage, Renal Dysfunction, Protective Potency and Wistar Rats