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Mechanism of Actin Filament Severing and Capping by Gelsolin
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Abstract
Gelsolin is the prototypical member of a family of Ca
2+
-dependent F-actin severing and capping proteins. A structure of Ca
2+
-bound full-length gelsolin at the barbed end shows domains G1G6 and the inter-domain linkers wrapping around F-actin. Another structure shows domains G1G3, a fragment produced during apoptosis, on both sides of F-actin. Conformational changes that trigger severing occur on one side of F-actin with G1G6 and on both sides with G1G3. Gelsolin remains bound after severing, blocking subunit exchange.
Title: Mechanism of Actin Filament Severing and Capping by Gelsolin
Description:
Abstract
Gelsolin is the prototypical member of a family of Ca
2+
-dependent F-actin severing and capping proteins.
A structure of Ca
2+
-bound full-length gelsolin at the barbed end shows domains G1G6 and the inter-domain linkers wrapping around F-actin.
Another structure shows domains G1G3, a fragment produced during apoptosis, on both sides of F-actin.
Conformational changes that trigger severing occur on one side of F-actin with G1G6 and on both sides with G1G3.
Gelsolin remains bound after severing, blocking subunit exchange.
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