Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
MyoD binds to Mos and inhibits the Mos/MAP kinase pathway
View through CrossRef
When ectopically expressed, the serine/threonine kinase Mos can induce oncogenic transformation of somatic cells by direct phosphorylation of MAP kinase/ERK kinase (MEK1), activating the mitogen‐activated protein kinases ERK1 and ERK2. On the other hand, overexpression of Mos in C2C12 myoblasts is not transforming. Mos activates myogenic differentiation by promoting heterodimerization of the MyoD/E12 proteins, increasing the expression of myogenic markers and the positive autoregulatory loop of MyoD. In this study, we show that in myogenic cells, the mitogenic and oncogenic signalling from the Mos/MEK/ERK pathway is suppressed by MyoD through the formation of a heterotrimeric complex.
Title: MyoD binds to Mos and inhibits the Mos/MAP kinase pathway
Description:
When ectopically expressed, the serine/threonine kinase Mos can induce oncogenic transformation of somatic cells by direct phosphorylation of MAP kinase/ERK kinase (MEK1), activating the mitogen‐activated protein kinases ERK1 and ERK2.
On the other hand, overexpression of Mos in C2C12 myoblasts is not transforming.
Mos activates myogenic differentiation by promoting heterodimerization of the MyoD/E12 proteins, increasing the expression of myogenic markers and the positive autoregulatory loop of MyoD.
In this study, we show that in myogenic cells, the mitogenic and oncogenic signalling from the Mos/MEK/ERK pathway is suppressed by MyoD through the formation of a heterotrimeric complex.
Related Results
Mutation of MyoD‐Ser237 abolishes its up‐regulation by c‐Mos
Mutation of MyoD‐Ser237 abolishes its up‐regulation by c‐Mos
Recently we have shown that Mos could activate myogenic differentiation by promoting heterodimerisation of MyoD and E12 proteins. Here, we demonstrate that MyoD can be efficiently ...
Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
Pbx homeodomain proteins direct Myod activity to promote fast-muscle differentiation
The basic helix-loop-helix (bHLH) transcription factor Myod directly regulates gene expression throughout the program of skeletal muscle differentiation. It is not known how a Myod...
Novel Combination Drug Regimens Using Hypomethylating Agents in Treatment of Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia
Novel Combination Drug Regimens Using Hypomethylating Agents in Treatment of Elderly Patients with Newly Diagnosed Acute Myeloid Leukemia
INTRODUCTION -The prognosis of acute myeloid leukemia (AML) in elderly population is inherently poor due to multiple factors including: frailty, medical co-morbidities and high tre...
The requirement of Mettl3-promoted
MyoD
mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation
The requirement of Mettl3-promoted
MyoD
mRNA maintenance in proliferative myoblasts for skeletal muscle differentiation
Myogenic progenitor/stem cells retain their skeletal muscle differentiation potential by maintaining myogenic transcription factors such as MyoD. However, the mechanism of how MyoD...
Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects
Cultured myf5 null and myoD null muscle precursor cells display distinct growth defects
Summry— Myf‐5 and MyoD are the two muscle regulatory factors expressed from the myoblast stage to maintain the identity and to promote the subsequent differentiation of muscle prec...
Negative Regulation by p70 S6 Kinase of FGF-2–Stimulated VEGF Release Through Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase in Osteoblasts
Negative Regulation by p70 S6 Kinase of FGF-2–Stimulated VEGF Release Through Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase in Osteoblasts
Abstract
To clarify the mechanism of VEGF release in osteoblasts, we studied whether p70 S6 kinase is involved in basic FGF-2–stimulated VEGF release in osteoblast-l...
Co-ordinated regulation of TNF expression by multiple MAP kinase pathways
Co-ordinated regulation of TNF expression by multiple MAP kinase pathways
Four MAP kinase pathways are currently believed to be activated in LPS stimulated macrophages: the ERK, JNK/SAPK, p38 and BMK/ERK5 pathways. We have evaluated the effect of each MA...
Amelioration of Enterotoxigenic Escherichia coli-induced disruption of intestinal epithelium by Manno-oligosaccharide in weaned pigs
Amelioration of Enterotoxigenic Escherichia coli-induced disruption of intestinal epithelium by Manno-oligosaccharide in weaned pigs
Abstract
Background: Enterotoxigenic Escherichia coli (ETEC) is one of the major bacterial causes leading to diarrhea and disruption of intestinal epithelium in neonatal an...