Gastric Xanthoma Biomarker Screening and Lipid Metabolism Mechanism Analysis as Potential Indicators for Gastric Cancer

The early detection of gastric cancer (GC) is critical for reducing its high mortality rates1,2. Gastric xanthoma (GX), a lipid-associated lesion in the gastric mucosa, has been identified as a precursor lesion for various stomach malignancies3,4 . In this study, we comprehensively explored the profiling of gut microbiota, lipid metabolism, and amino acid metabolism to identify novel biomarkers for the early detection of GX, with potential implications for GC prevention and treatment. Employing 16S rRNA sequencing5,6, transcriptomics 7, and gene ontology (GO) analyses8 , we uncovered significant correlations between gut microbiota composition, lipid transport dysregulation, and abnormal amino acid metabolism in GX. These findings highlight the role of lipid metabolism dysfunction9,10 and gut microbiota alterations11,12 in the pathogenesis of GX and suggest potential strategies for early GC detection and targeted therapy. Keywords: biomarkers, gastric xanthoma, lipid metabolism, 16S rRNA