Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Epstein‐barr virus‐specific antibodies in patients with adult T‐cell leukemia (ATL) and healthy ATL virus‐carriers
View through CrossRef
AbstractAntibodies to Epstein‐Barr virus (EBV)‐capsid antigen (VCA), early antigen (EA) and EBV‐associated nuclear antigen (EBNA) in the sera of 103 patients with adult T‐cell leukemia (ATL) and the sera of 243 age‐ and sex‐matched healthy adults, namely 99 anti‐ATLA‐positive (antibodies to ATL virus‐associated antigen) and 144 anti‐ATLA‐negative individuals, were determined by indirect immunofluorescence. The anti‐VCA titers in the sera from ATL patients were within the range observed in healthy controls. Anti‐EA was found in 27% of the sera from ATL patients, but in only 8% of the sera from anti‐ATLA‐negative healthy controls. Antibodies to EBNA, which were present in almost all healthy adults, were not found in 30% of the sera from ATL patients. Of the sera of anti‐ATLA‐positive healthy adult donors 11% were negative for EBNA antibody. These results suggest that functional impairment of the T‐cell system in most ATL patients, and also to a lesser extent in anti‐ATLA‐positive adults who might be healthy ATLV‐carriers, may cause an unusual immune response of antibodies to EBV‐associated antigens.
Title: Epstein‐barr virus‐specific antibodies in patients with adult T‐cell leukemia (ATL) and healthy ATL virus‐carriers
Description:
AbstractAntibodies to Epstein‐Barr virus (EBV)‐capsid antigen (VCA), early antigen (EA) and EBV‐associated nuclear antigen (EBNA) in the sera of 103 patients with adult T‐cell leukemia (ATL) and the sera of 243 age‐ and sex‐matched healthy adults, namely 99 anti‐ATLA‐positive (antibodies to ATL virus‐associated antigen) and 144 anti‐ATLA‐negative individuals, were determined by indirect immunofluorescence.
The anti‐VCA titers in the sera from ATL patients were within the range observed in healthy controls.
Anti‐EA was found in 27% of the sera from ATL patients, but in only 8% of the sera from anti‐ATLA‐negative healthy controls.
Antibodies to EBNA, which were present in almost all healthy adults, were not found in 30% of the sera from ATL patients.
Of the sera of anti‐ATLA‐positive healthy adult donors 11% were negative for EBNA antibody.
These results suggest that functional impairment of the T‐cell system in most ATL patients, and also to a lesser extent in anti‐ATLA‐positive adults who might be healthy ATLV‐carriers, may cause an unusual immune response of antibodies to EBV‐associated antigens.
Related Results
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Are Cervical Ribs Indicators of Childhood Cancer? A Narrative Review
Abstract
A cervical rib (CR), also known as a supernumerary or extra rib, is an additional rib that forms above the first rib, resulting from the overgrowth of the transverse proce...
Myosin-IIa Is Required for Leukemia Cell Extravasation and Its Inhibition Reduces Leukemia Dissemination and Prolongs Survival in a Mouse Model of Acute Lymphoblastic Leukemia
Myosin-IIa Is Required for Leukemia Cell Extravasation and Its Inhibition Reduces Leukemia Dissemination and Prolongs Survival in a Mouse Model of Acute Lymphoblastic Leukemia
Abstract
Background: Leukemia affects approximately 45,000 people each year in the USA with more than 20,000 fatalities. Many leukemia patients experience initial re...
STAT3 Mutations in Large Granular Lymphocytic Leukemia
STAT3 Mutations in Large Granular Lymphocytic Leukemia
Abstract
Abstract 1606
Introduction:
Large granular lymphocytic leukemia (LGL leukemia) is a rare lymphoprolifera...
Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.
Role of Allogeneic Stem Cell Transplantation for Adult T-Cell Leukemia in an HTLV-1 Non-Endemic Area of Japan.
Abstract
Abstract 3089
Adult T-cell leukemia/lymphoma (ATL) mainly occurs in HTLV-1 endemic areas such as the southwest island in Japan (Kyushu) and C...
Outcomes of Allogeneic Transplantation for Adult T-Cell Leukemia/Lymphoma in Adolescents and Young Adult (AYA) and Young Patients
Outcomes of Allogeneic Transplantation for Adult T-Cell Leukemia/Lymphoma in Adolescents and Young Adult (AYA) and Young Patients
Introduction
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) provides a durable remission for patients with adult T-cell leukemia/lymphoma (ATL). Redu...
MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing v1
MARS-seq2.0: an experimental and analytical pipeline for indexed sorting combined with single-cell RNA sequencing v1
Human tissues comprise trillions of cells that populate a complex space of molecular phenotypes and functions and that vary in abundance by 4–9 orders of magnitude. Relying solely ...
Alantolactone Exhibits Antiproliferative and Apoptosis-Promoting Properties in Colon Cancer Model via Activation of the MAPK-JNK/c-Jun Signaling Pathway
Alantolactone Exhibits Antiproliferative and Apoptosis-Promoting Properties in Colon Cancer Model via Activation of the MAPK-JNK/c-Jun Signaling Pathway
Abstract
Colorectal cancer (CRC) is one of the most common human malignancies in the digestive tract with high mortality. Alantolactone (ATL), as a plant-derived sesquiterp...
Abstract 132: African polyherbal formulation alleviates benzene-induced leukemia in Wistar rats
Abstract 132: African polyherbal formulation alleviates benzene-induced leukemia in Wistar rats
Abstract
Background: Chemotherapy and radiotherapy are effective cancer treatment options but they are accompanied by serious side effects. Therefore, more effective...