Search engine for discovering works of Art, research articles, and books related to Art and Culture
Javascript must be enabled to continue!
Development of novel plant-based adjuvant formulation against rubella and hepatitis B vaccine antigen
View through CrossRef
Summary
Introduction: Numerous metabolites present in the aqueous extract from plants are responsible for inducing adjuvant activity against rubella and hepatitis B vaccine antigen (HBsAg). One of the medicinal plants, Adhatoda vasica has been pointed out with great potential of vaccine adjuvant property.
Objective: The objective of our study is to evaluate the adjuvant potential of aqueous leaves extract of Adhatoda vasica against rubella and hepatitis B vaccine antigen (HBsAg).
Methods: For these studies, our group evaluated the antibody (IgG) titre of HBsAg and rubella vaccine antigen using variable doses (0.625–5 mg) of aqueous leaves extract of Adhatoda vasica and also determined the lymphocyte (splenocyte) proliferation assay (0.625–5 mg; 50 μl) in mice model studies ex vivo (i.e. immunized with HBsAg subcutaneously).
Results: The results showed that aqueous leaves extract showed anti-HBsAg and anti-rubella titre and also enhanced the lymphocyte proliferation assay at higher doses (5 mg) as compared to control.
Conclusion: Aqueous leaves extract of Adhatoda vasica showed adjuvant activity against HBsAg and rubella vaccine antigen.
Title: Development of novel plant-based adjuvant formulation against rubella and hepatitis B vaccine antigen
Description:
Summary
Introduction: Numerous metabolites present in the aqueous extract from plants are responsible for inducing adjuvant activity against rubella and hepatitis B vaccine antigen (HBsAg).
One of the medicinal plants, Adhatoda vasica has been pointed out with great potential of vaccine adjuvant property.
Objective: The objective of our study is to evaluate the adjuvant potential of aqueous leaves extract of Adhatoda vasica against rubella and hepatitis B vaccine antigen (HBsAg).
Methods: For these studies, our group evaluated the antibody (IgG) titre of HBsAg and rubella vaccine antigen using variable doses (0.
625–5 mg) of aqueous leaves extract of Adhatoda vasica and also determined the lymphocyte (splenocyte) proliferation assay (0.
625–5 mg; 50 μl) in mice model studies ex vivo (i.
e.
immunized with HBsAg subcutaneously).
Results: The results showed that aqueous leaves extract showed anti-HBsAg and anti-rubella titre and also enhanced the lymphocyte proliferation assay at higher doses (5 mg) as compared to control.
Conclusion: Aqueous leaves extract of Adhatoda vasica showed adjuvant activity against HBsAg and rubella vaccine antigen.
Related Results
The Impact of IL28B Gene Polymorphisms on Drug Responses
The Impact of IL28B Gene Polymorphisms on Drug Responses
To achieve high therapeutic efficacy in the patient, information on pharmacokinetics, pharmacodynamics, and pharmacogenetics is required. With the development of science and techno...
One-point evaluation of children exposed to rubella infection In Utero in Maiduguri, North-Eastern Nigeria: A follow-up Study
One-point evaluation of children exposed to rubella infection In Utero in Maiduguri, North-Eastern Nigeria: A follow-up Study
Background: Rubella is a disease caused by a virus, rubella virus. Major obstetrics concerns are profound effects of the virus on developing fetuses, which may result in multiple c...
Epidemiology of rubella infection in Cameroon: a 7-year experience of measles and rubella case-based surveillance, 2008–2014
Epidemiology of rubella infection in Cameroon: a 7-year experience of measles and rubella case-based surveillance, 2008–2014
ObjectiveThe aim of this study was to estimate the proportion of rubella disease in a measles case-based surveillance in Cameroon prior to rubella vaccine introduction into the nat...
Epidemiological analysis of rubella-confirmed cases from measles-suspected cases in Ethiopia: threat for congenital rubella syndrome
Epidemiological analysis of rubella-confirmed cases from measles-suspected cases in Ethiopia: threat for congenital rubella syndrome
Abstract
Rubella is a highly contagious mild viral illness. It is a leading cause of congenital rubella syndrome (CRS). Routine data of rubella do not exist in Ethiopia. However...
The evolving landscape of rubella in the WHO African Region
The evolving landscape of rubella in the WHO African Region
Introduction: as of the end of 2024, a total of 35 countries in the World Health Organization (WHO) African Region have introduced rubella vaccine. Globally, rubella cases declined...
Burden of the Beast
Burden of the Beast
Introduction
Throughout the COVID-19 pandemic, and its fluctuating waves of infections and the emergence of new variants, Indigenous populations in Australia and worldwide have re...
IgM antibody to hepatitis C virus in acute and chronic hepatitis C
IgM antibody to hepatitis C virus in acute and chronic hepatitis C
To assess possible role of testing for IgM-specific antibody in the diagnosis and monitoring of patients with hepatitis C, we tested sera from 14 patients with acute and 97 patient...
Polio eradication in Africa: overcoming the final hurdles
Polio eradication in Africa: overcoming the final hurdles
Introduction: rubella infection in the first trimester of pregnancy can cause fetal organ damage and manifest as congenital rubella syndrome (CRS) in live-born babies. Global estim...